Linda van Zutphen

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Due to their aggressive nature, male mice are less frequently used than female mice in biomedical research. When aggressive males are being used, individual housing is common practice. The question arises whether this is an acceptable housing for a social species. The present study was designed to gain more insight into the nature of inter-male social(More)
Environmental enrichment may improve the quality of life of captive animals by altering the environment of animals so that they are able to perform more of the behavior that is within the range of the animal's species-specific repertoire. When enrichment is introduced into an animal's environment, it is important to evaluate the effect of the enrichment(More)
Behavioural and psychological needs of laboratory animals generally cannot adequately be met in standard laboratory cages. Environmental enrichment, which provides a more structured environment can enhance the well-being of laboratory animals. They may perform more of their species-specific behaviour and may control their environment in a better way. An(More)
The effects of gene-targeting procedures on the behavior and physiological development of (chimeric) mice have been investigated. We used six groups of mice, each of them undergoing specific aspects of the biotechnological procedure, including electroporation, microinjection, and/or blastocyst culture. Changes in behavior and physiological development of(More)
Emotional sensitivity, emotion regulation and impulsivity are fundamental topics in research of borderline personality disorder (BPD). Studies using fMRI examining the neural correlates concerning these topics is growing and has just begun understanding the underlying neural correlates in BPD. However, there are strong similarities but also important(More)
The influence of environmental enrichment on the behaviour of the mouse has been studied in two inbred strains (C57BL and BALB/c). Male mice of each of the two strains were subjected to behavioural tests after being housed for two months either under standard housing conditions or in an enriched environment. The results of the behavioural test indicated(More)
In this study we investigated the effect of environmental enrichment and handling on the acute physiological stress response caused by short periods of restraint in individually housed female mice. Heart rate (HR) and body temperature (BT) were measured by radiotelemetry and compared with plasma corticosterone (pCORT) levels. Also, postmortem thymus weight(More)
The term competence, as it first appeared in the European guidelines, was rather poorly defined and hence resulted in some confusion. It was FELASA'sinitiative in working with the various competence categories, which made the concept clear and comprehensive. According to FELASAthere are four competence categories (FELASA1995): Category A-Animal technicians(More)
From welfare perspective group housing of mice is preferred over individual housing. Group housing of male laboratory mice, however, often leads to problems due to excessive aggressive behaviour. In our search for management and housing modi®cations to decrease aggression in group-housed male laboratory mice, we have tested the effect of two types of(More)
Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala(More)