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The overwhelming majority of research into the design and analysis of simulation assumes that only a single response variable is of interest to the researcher. This is an impractical assumption. In these introductory remarks, the problem of multiple response in simulation analysis is addressed and some solutions are discussed.
Living skin equivalents (SE) were prepared by combining cultured fibroblasts with a collagen matrix and overlaying this lattice with keratinocytes. SEs prepared using allogeneic female rat fibroblasts or xenogeneic rabbit or human fibroblasts and keratinocytes isogeneic to the graft recipient were transplanted to recipient male rats. Biopsies of some of… (More)
The general linear metamodel has been found to be an effective tool in post-simulation analysis. This paper addresses the multiple response problem in simulation and proposes a multivariate general linear metamodel as an aid in understanding and interpreting simulation results. Such a metamodel was developed using multiple response data generated from an… (More)