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— This paper concerns with stability characteristics of active disturbance rejection control for nonlinear time-varying plants that are largely unknown. In particular, as-ymptotic stability is established where the plant dynamics is completely known. In the face of large dynamic uncertainties, estimation and tracking errors are shown to be bounded, with(More)
This paper is concerned with the question of, for a physical plant to be controlled, whether or not its internal dynamics and external disturbances can be realistically estimated in real time from its input-output data. A positive answer would have significant implications on control system design, because it means that an accurate model of the plant is(More)
SUMMARY The activation of oncogenes in primary cells blocks proliferation by inducing oncogene-induced senescence (OIS), a highly potent in vivo tumor-suppressing program. A prime example is mutant BRAF, which drives OIS in melanocytic nevi. Progression to melanoma occurs only in the context of additional alteration(s) like the suppression of PTEN, which(More)
This is a PDF file of an unedited peer-reviewed manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be(More)
Cutaneous melanoma, a type of skin tumor originating from melanocytes, often develops from premalignant naevoid lesions via a gradual transformation process driven by an accumulation of (epi)genetic lesions. These dysplastic naevi display altered morphology and often proliferation of melanocytes. Additionally, melanocytes in dysplastic naevi show structural(More)
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