Linda Padilla

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The anticancer drug doxorubicin (DOX) has been linked to chimeric BR96, an internalizing monoclonal antibody that binds to a Lewis(y)-related, tumor-associated antigen, through two lysosomally cleavable dipeptides, Phe-Lys and Val-Cit, giving immunoconjugates 72 and 73. A self-immolative p-aminobenzyloxycarbonyl (PABC) spacer between the dipeptides and the(More)
Group B Streptococcal (GBS) antibiotic susceptibility studies were performed in 95 pregnant women in Bridgeport, Connecticut. Testing for penicillin, ampicillin, cefazolin, and clindamycin sensitivity was performed. Resistance to clindamycin was seen in 5% of isolates. All isolates were susceptible to penicillin, ampicillin, and cefazolin. Clindamycin(More)
This work presents a virtual experiment with haptic interaction for illustrating one method of determining the Young Modulus — a property related to material stiffness and, therefore, one of the most important property in engineering design. The HapticBender is an evolution of an existing system where new features have been integrated.
It is desirable to be able to control the pH of lysosomes. A collection of lipophilic, nitrogenous bases, designed to act as membrane-active, catalytic proton transfer agents, were prepared and their effective pK(a)s measured in a vigorously stirred, two-phase system. One phase was a phosphate buffer whose pH was varied over the range ca. 1-11. The other(More)
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