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BACKGROUND Death within 90 days after total hip replacement is rare but might be avoidable dependent on patient and treatment factors. We assessed whether a secular decrease in death caused by hip replacement has occurred in England and Wales and whether modifiable perioperative factors exist that could reduce deaths. METHODS We took data about hip(More)
The kinematics of the wrist and a manipulated object were studied in a posting task in 30 control, eight hemiplegic and 10 diplegic children. Statistical analyses using 'mixed' models examined the effects of subject group, hand, object shape and repeated trials, together with all possible interaction terms. During transport to the posting hole, the number(More)
A shape-posting task was studied in 30 control, eight hemiplegic and 10 diplegic children, to determine how differences in object manipulation between such children could be quantified. Conical, cylindrical and triangular-shaped objects were posted through a hole in a perspex screen, three times each with both preferred and non-preferred hands. Four(More)
The efficacy of allografting in acute lymphoblastic leukemia (ALL) is heavily influenced by remission status at the time of transplant. Using polymerase chain reaction (PCR)-based minimal residual disease (MRD) analysis, we have investigated retrospectively the impact of submicroscopic leukemia on outcome in 64 patients receiving allogeneic bone marrow(More)
OBJECTIVE To investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood cortisol. METHODS A total of 16 people (8 female) with active RA and who had received no recent(More)
BACKGROUND Preterm birth remains a major public health problem and its incidence worldwide is increasing. Epidemiological risk factors have been investigated in the past, but there is a need for a better understanding of the causes of preterm birth in well defined obstetric populations in tertiary referral centres; it is important to repeat surveillance and(More)
BACKGROUND Understanding the risk factors for early death after knee replacement could help to reduce the risk of mortality after this procedure. We assessed secular trends in death within 45 days of knee replacement for osteoarthritis in England and Wales, with the aim of investigating whether any change that we recorded could be explained by alterations(More)
in the period 1971-94. These data showed a 16% excess of cases diagnosed in the summer months (May-October) in children (95% confidence interval 1.02-1.30), and a 20% excess in adults (95% confidence interval 1.03-1.37). Using the same fairly crude technique as Badrinath et al (1997) on two datasets (which covered slightly different age and diagnostic(More)
BACKGROUND Overexpression of carbonic anhydrase (CA IX) is associated with poor survival in several adult-type cancers but its expression is undocumented in Wilms tumour (WT), the most common tumour of the paediatric kidney. METHODS CA9 expression was measured using polymerase chain reaction (PCR) in 13 WTs and matched-paired non-neoplastic kidneys (NKs).(More)
BACKGROUND Prosthetic hip implants have many combinations of bearing surface materials, sizes, and fixation techniques, which can determine the quality of life of patients after primary total hip replacement (THR) and the likelihood of needing revision surgery. When an implant fails, patients require revision THR, which is distressing to the patient and(More)