Learn More
Primary open angle glaucoma (POAG) is a progressive optic neuropathy characterized by retinal ganglion cell loss. Experimental primate glaucoma indicates neuronal degeneration of the lateral geniculate nucleus (LGN) and activity changes in the visual cortex (V1). Neuronal degeneration has also been shown in a post-mortem human study of the optic nerve, LGN(More)
PURPOSE To present and evaluate a new method of estimating rates of retinal ganglion cell (RGC) loss in glaucoma by combining structural and functional measurements. DESIGN Observational cohort study. METHODS The study included 213 eyes of 213 glaucoma patients followed up for an average of 4.5 ± 0.8 years with standard automated perimetry visual fields(More)
PURPOSE To evaluate choroidal thickness (CT) in healthy and glaucomatous eyes using Swept Source Optical Coherence Tomography (SS-OCT). METHODS A cross-sectional observational study of 216 eyes of 140 subjects with glaucoma and 106 eyes of 67 healthy subjects enrolled in the Diagnostic Innovations in Glaucoma Study. CT was assessed from wide-field (12×9(More)
10 Glaucoma is the second leading cause of blindness worldwide. Often the optic nerve head 11 (ONH) glaucomatous damage and ONH changes occur prior to visual field loss and are observ-12 able in vivo. Thus digital image analysis is a promising choice for detecting the onset and/or 13 progression of glaucoma. In this work, we present a new framework for(More)
PURPOSE To compare the abilities of scanning laser polarimetry (SLP), optical coherence tomography (OCT), short-wavelength automated perimetry (SWAP), and frequency-doubling technology (FDT) perimetry to discriminate between healthy eyes and those with early glaucoma, classified based on standard automated perimetry (SAP) and optic disc appearance. To(More)
PURPOSE To determine which machine learning classifier learns best to interpret standard automated perimetry (SAP) and to compare the best of the machine classifiers with the global indices of STATPAC 2 and with experts in glaucoma. METHODS Multilayer perceptrons (MLP), support vector machines (SVM), mixture of Gaussian (MoG), and mixture of generalized(More)
PURPOSE To determine whether neural network techniques can improve differentiation between glaucomatous and nonglaucomatous eyes, using the optic disc topography parameters of the Heidelberg Retina Tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany). METHODS With the HRT, one eye was imaged from each of 108 patients with glaucoma (defined as(More)
PURPOSE To evaluate the association between quantitative nerve fiber layer measurements and visual field loss in patients with primary open-angle glaucoma. METHODS Quantitative retinal nerve fiber layer measurements were obtained in 53 patients with primary open-angle glaucoma by using confocal scanning laser ophthalmoscopy (cross-section area) and(More)
PURPOSE To demonstrate that the relationship between the functional organization of primary visual cortex (V1) and damage to the optic disc in humans with primary open-angle glaucoma (POAG) can be measured using a novel method for projecting scotomas onto the flattened cortical representation. METHODS Six subjects participated in this functional magnetic(More)
PURPOSE To determine the relationship between areas of glaucomatous retinal nerve fiber layer thinning identified by optical coherence tomography and areas of decreased visual field sensitivity identified by standard automated perimetry in glaucomatous eyes. DESIGN Retrospective observational case series. PARTICIPANTS Forty-three patients with(More)