Linda M. Harrison

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In adults, motoneurone pools of synergistic muscles that act around a common joint share a common presynaptic drive. Common drive can be revealed by both time domain and frequency domain analysis of EMG signals. Analysis in the frequency domain reveals significant coherence in the range 1-45 Hz, with maximal coherence in low (1-12 Hz) and high (16-32 Hz)(More)
Changes in cutaneomuscular reflex responses (CMRs) have been studied in relation to normal ageing in man. Multiunit surface EMG signals were recorded from right and left first dorsal interosseous (1DI) hand muscles from 23 elderly adults (mean age 71.1, range 58–88 years) and 11 young adults (mean age 25.9, range 19–31 years). Subjects (1) performed index(More)
The use of corticosteroids, such as betamethasone, in performance horses is tightly regulated. The objective of the current study was to describe the plasma pharmacokinetics of betamethasone as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve racing-fit adult Thoroughbred horses received(More)
Cutaneomuscular reflex responses (CMRs) have been studied in nine stroke patients (55-84 years) starting from the first 1-7 weeks after stroke and continuing at intervals of 6-8 weeks for up to 2 years. Multi-unit surface EMG signals were recorded from the stroke and non-stroke first dorsal interosseous (1DI) hand muscle while subjects gripped a dowel, and(More)
BACKGROUND Intra-articular use of corticosteroids is commonplace in performance horses. Isoflupredone acetate (IPA) is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses. The lack of published reports describing the efficacy and duration of effects of this drug warrant further study. OBJECTIVES To assess(More)
Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in horses and as such the potential to affect performance. Clenbuterol decreases the percent fat and increases(More)
The use of isoflupredone acetate in performance horses and the scarcity of published pharmacokinetic data necessitate further study. The objective of the current study was to describe the plasma pharmacokinetics of isoflupredone acetate as well as time-related urine and synovial fluid concentrations following intra-articular administration to horses. Twelve(More)
Cutaneomuscular reflex (CMR) responses and motor unit synchronisation have been recorded to investigate possible reorganisation of central nervous pathways in six healthy adults learning a novel skill with the non-dominant hand. Multi-unit surface EMG signals were recorded from first dorsal interosseous (1DI) and abductor digiti minimi (ADM) muscles during(More)
Methylprednisolone acetate (MPA) is commonly administered to performance horses, and therefore, establishing appropriate withdrawal times prior to performance is critical. The objectives of this study were to describe the plasma pharmacokinetics of MPA and time-related urine and synovial fluid concentrations following intra-articular administration to(More)
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