Linda M. Harrison

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In adults, motoneurone pools of synergistic muscles that act around a common joint share a common presynaptic drive. Common drive can be revealed by both time domain and frequency domain analysis of EMG signals. Analysis in the frequency domain reveals significant coherence in the range 1-45 Hz, with maximal coherence in low (1-12 Hz) and high (16-32 Hz)(More)
Cutaneomuscular reflex responses (CMRs) have been studied in nine stroke patients (55-84 years) starting from the first 1-7 weeks after stroke and continuing at intervals of 6-8 weeks for up to 2 years. Multi-unit surface EMG signals were recorded from the stroke and non-stroke first dorsal interosseous (1DI) hand muscle while subjects gripped a dowel, and(More)
INTRODUCTION Patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) become progressively impaired, with chronic pain, immobility and bladder, bowel and sexual dysfunction. Tested antiretroviral therapies have not been effective and most patients are offered a short course of corticosteroids or interferon-α, physiotherapy and(More)
The aim of this paper is to reassess the significance of postmortem cerebrospinal fluid pleocytosis. Published articles of CSF changes after death were reviewed, and reanalysis, in the light of modern views on the significance of bacterial postmortem isolates, was undertaken. There is theoretical and experimental evidence that the blood brain barrier to the(More)
Changes in cutaneomuscular reflex responses (CMRs) have been studied in relation to normal ageing in man. Multiunit surface EMG signals were recorded from right and left first dorsal interosseous (1DI) hand muscles from 23 elderly adults (mean age 71.1, range 58-88 years) and 11 young adults (mean age 25.9, range 19-31 years). Subjects (1) performed index(More)
There have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA 11, HIV-infected children were randomised to CD4-guided PTIs (n = 53) or continuous therapy (CT, n = 56). Carers, and children if appropriate,(More)
BACKGROUND The International Maternal, Pediatric, and Adolescent Clinical Trials P1060 trial demonstrated superior outcomes for HIV-infected children less than 3 years old initiating antiretroviral therapy (ART) with lopinavir/ritonavir compared to nevirapine, but lopinavir/ritonavir is four-fold costlier. DESIGN/METHODS We used the Cost-Effectiveness of(More)
Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in horses and as such the potential to affect performance. Clenbuterol decreases the percent fat and increases(More)