Linda M. Dansby

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While the fractional excretion of solutes have long been considered excellent research tools to investigate tubular physiology, their clinical use has become common over the last 40 years in the diagnoses of many disorders; however, none have reached the clinical utility of the fractional excretion of sodium in the ability to distinguish pre-renal azotemia(More)
Several properties of four 1-deaza-7,8-dihydropteridines were compared with those of each other and with those of colchicine, nocodazole, podophyllotoxin, and vincristine. Compound NSC 370147 was more active than the other compounds of this type with respect to inhibition of proliferation of cultured L1210 cells and to increase of the mitotic index. On an(More)
Sir, I would like to thank Lars Weiss for his interesting comments regarding my Editorial Comment [1] from over a year ago! However, I do have some difficulty accepting one or two of his arguments. While one cannot completely exclude the possibility of different pharmacodynamics between epoetin alfa and epoetin beta, I feel it is unlikely that a difference(More)
AIM To evaluate whether factors such as acidosis and hyperphosphataemia that might cause an increased oxygen delivery to tissues could result in increased dosing requirements for intravenous erythropoietin (EPO) administration given to haemodialysis patients. METHODS The clinical records of the patients seen at the Hypertension, Nephrology, Dialysis and(More)
BACKGROUND The fractional excretion of urea (FeUrea) may result in more reliable in the determination of renal function than sodium in the presence of oliguric azotemia; however, its usefulness remains controversial, perhaps due to an evolving understanding of urea transport within the kidney. METHODS This was a prospective observational study of 100(More)
BACKGROUND Biofilms are dense aggregates of surface adherent microorganisms embedded in a polysaccharide matrix. Intravenous iron and heparin are thought to promote the formation of biofilm. Both are commonly employed during hemodialysis treatments which might affect the incidence of catheter-related sepsis. METHODS 559 patients who underwent hemodialysis(More)
Maintenance of a functioning vascular access for hemodialysis is a major challenge for nephrologists, vascular surgeons and—most importantly—the patients themselves. Greater insight into the pathophysiology of access thrombosis, stenosis, aneurysm formation, fistula maturation failure and catheter infection will aid the development of innovative ways to(More)