Linda Longo

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Prenatal maternal infection represents a risk factor for the development of psychopathologic conditions later in life. Clinical evidence is also supported by animal models in which the vulnerability to develop a schizophrenic-like phenotype likely originates from inflammatory processes as early as in the womb. Prenatal immune challenge, for example, induces(More)
Prenatal maternal infection represents a risk factor for schizophrenia and related disorders. In rodents, prenatal immune challenge with the viral mimetic poly(I:C) (polyriboinosinic-polyribocytidilic-acid) induces long-term behavioral deficits, highly relevant for schizophrenia and neurodevelopmental disorders. We have previously shown that the behavioral(More)
Prenatal stress (PNS) might affect the developmental programming of adult chronic diseases such as metabolic and mood disorders. The molecular mechanisms underlying such regulations may rely upon long-term changes in stress-responsive effectors such as Brain-Derived Neurotrophic Factor (BDNF) that can affect neuronal plasticity underlying mood disorders and(More)
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