Linda Linton

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OBJECTIVE The York Incontinence Perceptions Scale (YIPS) was developed to measure the psychosocial aspects of urinary incontinence and its management. DESIGN Testing of internal consistency and validity of the YIPS. SETTING AND PARTICIPANTS Subjects were 101 female rural community residents (mean age = 67.4 years) diagnosed with urinary incontinence and(More)
Our research has demonstrated that the lateral habenular nucleus (Lhb) is necessary for the hormonal onset but not the postpartum maintenance of maternal behavior in the rat (K. P. Corodimas, J. S. Rosenblatt, & J. I. Morrell, 1992; K. P. Corodimas, J. S. Rosenblatt, M. E. Canfield, & J. I. Morell, 1993; T. Matthews-Felton, K. P. Corodimas, J. S.(More)
Mammographic breast density is a highly heritable (h2 > 0.6) and strong risk factor for breast cancer. We conducted a genome-wide linkage study to identify loci influencing mammographic breast density (MD). Epidemiological data were assembled on 1,415 families from the Australia, Northern California and Ontario sites of the Breast Cancer Family Registry,(More)
Percent mammographic density (PMD) is a strong and highly heritable risk factor for breast cancer. Studies of the role of PMD in familial breast cancer may require controls, such as the sisters of cases, selected from the same 'risk set' as the cases. The use of sister controls would allow control for factors that have been shown to influence risk of breast(More)
BACKGROUND Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. METHODS AND FINDINGS We examined cross-sectional differences in MD by age and menopausal status in over 11,000(More)
We demonstrated previously that the lateral habenula (Lhb) mediates maternal behavior. Our present goal was to identify the first and second order afferent connections of the Lhb, particularly those relevant for maternal behavior. Using pseudorabies virus (PRV) as a retrograde transneuronal tracer and the retrograde tracer Fluoro-Gold, we identified first(More)
Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with(More)
Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/digital) and digital image format (raw/processed). We aimed to examine differences in MD assessed on these image types. We obtained 1294 pairs of images(More)
David Hettle1*, Linda Linton2, Julien S Baker3 and Orna Donoghue4 1University of Edinburgh Medical School, University of Edinburgh, United Kingdom 2FASIC, Centre for Sport and Exercise, University of Edinburgh, United Kingdom 3Institute of Clinical Exercise and Health Science, University of the West of Scotland, United Kingdom 4Institute of Sport, Physical(More)
The natural onset of maternal behavior in the rat is hormonally mediated. Estrogen, progesterone, and prolactin administered to ovariectomized females in amounts and sequences that produce circulating levels similar to those found during pregnancy stimulate the onset of maternal behavior. In fact, maternal behavior can be stimulated by estrogen alone,(More)