We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation… (More)
Afferent and efferent connections of the thalamic eminence of the axolotl were determined using the fluorescent compound DiI as a tracer. The thalamic eminence is connected reciprocally with a number of telencephalic and diencephalic areas, particularly with the medial pallium, the amygdala and the preoptic region. Efferent connections are widespread… (More)
Schizophrenia is a serious and chronic mental disorder, in which both genetic and environmental factors have a role in the development of the disease. Neuregulin-1 (NRG1) is one of the most established genetic risk factors for schizophrenia, and disruption of NRG1 signaling has been reported in this disorder. We reported previously that NRG1/ErbB4 signaling… (More)
131 The College of Liberal Arts emphasizes the foundation of knowledge through critical thinking, imagination, curiosity, healthy doubt tempered by wisdom, tolerance, and a sense of humor.
The evolutionarily conserved IGF-1 signalling pathway is associated with longevity, metabolism, tissue homeostasis, and cancer progression. Its regulation relies on the delicate balance between activating kinases and suppressing phosphatases and is still not very well understood. We report here that IGF-1 signalling in vitro and in a murine ageing model in… (More)