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Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema(More)
BACKGROUND Chronic obstructive pulmonary disease and emphysema are a frequent result of long-term smoking, but the exact mechanisms, specifically which types of cells are associated with the lung destruction, are unclear. METHODS AND FINDINGS We studied different subsets of lymphocytes taken from portions of human lungs removed surgically to find out(More)
STUDY OBJECTIVES To determine the transbronchial needle aspiration (TBNA) yield for procedures performed by fellows in training, and the predictors of positive TBNA yield at our center. DESIGN Retrospective chart review. SETTING A tertiary teaching hospital. PATIENTS One hundred seventy patients who underwent fiberoptic bronchoscopy with TBNA of(More)
We sought to determine the effect of statin therapy on serum AST and ALT levels in a cohort of HCV-infected veterans with well-characterized liver disease. We examined liver biopsy records of consecutive HCV-infected patients and identified 20 patients who were prescribed statins. We matched them on age, stage of fibrosis, and time between HCV diagnosis and(More)
Seventy-eight advanced breast cancer patients, most of whom had had prior treatment, were treated with the synthetic antiestogen tamoxifen. The overall objective response rate was 27% (21/78). An additional 19% (15/78) showed disease stabilization. Sixty-seven percent (14/21) of the responses were in soft tissue sites, 24% (5/21) on bony sites and one each(More)
OBJECTIVES There are no guidelines regarding the best practice for when Barrett's esophagus (BE) is suspected but not confirmed by histology. The aim of this study was to examine the value of endoscopic follow-up for individuals with endoscopic only BE at index endoscopy. METHODS We performed a longitudinal study of patients diagnosed with suspected(More)
A patient with previous resection of primary hepatocellular carcinoma developed upper intestinal bleeding. Pinch biopsy and needle aspiration biopsy of a submucosal antral lesion seen at endoscopy yielded metastatic hepatoma. We believe this to be the first report of the endoscopic appearance of a submucosal tumor. Currently available methods of tissue(More)
OBJECTIVES Esophageal adenocarcinoma is more common among non-Hispanic Whites (NHWs) than African Americans (AAs). It is unclear whether its precursor, Barrett's esophagus (BE), is also less common among AAs, and whether differences in risk factor profiles explain the racial disparity. METHODS Data were from a case-control study among eligible Veterans(More)