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We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A and ten "control" genomes. We summarize the number of genetic variants emerging from a study of this(More)
Imaging of the human body by any non-invasive technique has been an appropriate goal of physics and medicine, and great success has been obtained with both Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) in brain imaging. Non-imaging responses to functional activation using near infrared spectroscopy of brain (fNIR) obtained in 1993(More)
PURPOSE To evaluate the variations of multi-lumen balloon (MLB)-based brachytherapy from simulation day to treatment day and their dosimetric impacts during accelerated partial breast irradiation (APBI). MATERIAL AND METHODS A total of 42 CT images scanned from seven patients were evaluated with regards to daily variation due to of: 1) internal(More)
PURPOSE A cylinder applicator is the standard treatment device for intravaginal brachytherapy. However, they are limited in their ability to simultaneously spare the organs at risk (OAR), and reduce the hot spot in the vaginal mucosa, while achieving adequate dose conformality. This study aims to compare the dosimetric characteristics of single and(More)
Structural coloration produces some of the most brilliant colors in nature and has many applications. Motivated by the recently proposed transparent displays that are based on wavelength-selective scattering, here we consider the new problem of transparent structural color, where objects are transparent under omnidirectional broad-band illumination but(More)
BACKGROUND To evaluate and compare the biological impact on different proposed margin recipes for the same geometric uncertainties for intra-hepatic tumors with different tumor cell types or clinical stages. METHOD Three different margin recipes based on tumor motion were applied to sixteen IMRT plans with a total of twenty two intra-hepatic tumors. One(More)
Intensity modulated radiotherapy (IMRT) has become an effective tool for cancer treatment with radiation. However, even expert radiation planners still need to spend a substantial amount of time adjusting IMRT optimization parameters in order to get a clinically acceptable plan. We demonstrate that the relationship between patient geometry and radiation(More)
In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called " Globally Convergent Method " (GCM) based upon actual measurements taken from(More)
Most deformation algorithms use a single-value smoother during optimization. We investigate multi-scale regularizations (smoothers) during the multi-resolution iteration of two non-parametric deformable registrations (demons and diffeomorphic algorithms) and compare them to a conventional single-value smoother. Our results show that as smoothers increase,(More)