Linda Hasselberg

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Offshore oil production releases large amounts of lipophilic compounds in produced water and into the ocean. The discharge of produced water from the Norwegian petroleum sector has increased from 26 million m3 in 1993 to 120 million m3 in 2001, and it continues to increase. Produced water contains significant amounts of alkylphenols, which have been(More)
A consequence of oil drilling at sea is the release of produced water contaminated with e.g. polycyclic aromatic hydrocarbons (PAH) and alkylphenols. In the present study, juvenile Atlantic cod were exposed to North Sea oil, nonylphenol and a combination of the North Sea oil and an alkylphenol mixture in a flow-through system. A suite of hepatic biomarkers(More)
Rubber tire material contains toxic compounds including oils rich in polycyclic aromatic hydrocarbons (PAH), so-called highly aromatic (HA) oils, as well as other reactive additives used as antioxidants, antiozonants, and vulcanization accelerators. The toxicity of rubber tire leachates to aquatic organisms has been demonstrated before. However, previous(More)
Alkylphenols are continuously released into the ocean as a result of offshore oil production. Alkylphenols, including 4-tert-butylphenol (C4), 4n-pentylphenol (C5), 4n-hexylphenol (C6), and 4n-heptylphenol (C7), up to 237 ppb concentrations, have been detected in produced water from oil platforms. Previous studies have shown that alkylphenols induce(More)
Background: Xenoestrogens and antifungal azoles probably share a common route of metabolism, through hepatic cytochrome P450 (CYP) enzymes. Chemical interactions with metabolic pathways may affect clearance of both xenobiotics and endobiotics. This study was carried out to identify possible chemical interactions by those substances on CYP1A and CYP3A, in(More)
The transcriptional levels of 10 genes were quantified in liver of Atlantic cod exposed to environmental relevant concentrations of three model toxicants; two alkylphenols (30 microg/L nonylphenol (NP) and 50 microg/L bisphenol A (BPA)) and one brominated flame-retardant congener (5 microg/L PBDE-47). The fish were exposed to the toxicants for 3 weeks, with(More)
This study focuses on effects of two classes of xenobiotics, azole fungicides and xenoestrogens, both of which have been detected in the aquatic environment. We hypothesize that azoles and estrogenic compounds are metabolized by cytochrome P450 (CYP) enzymes, and in particular CYP1A and CYP3A, to more readily excreted metabolites. We exposed rainbow trout(More)
Foreword There is a great need for more knowledge of the effects on the marine environment of discharges to the sea from the offshore oil and gas industry. The long-term effects in particular are of great interest, as we know very little about them. More knowledge is thus essential if the authorities are to be able to control the development of this sector(More)
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