Linda E. Reed

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A major disadvantage of (131)iodine (I)-labeled monoclonal antibodies (MAbs) for radioimmunotherapy has been the rapid diffusion of iodotyrosine from target cells after internalization and catabolism of the radioiodinated MAbs. We recently reported that a radioiodinated, diethylenetriaminepentaacetic acid-appended peptide, designated immunomedics'(More)
BACKGROUND To enhance the efficacy of chemotherapy for medullary thyroid carcinoma (MTC), we evaluated the effect of combining radioimmunotherapy (RAIT) with 90Y-anticarcinoembryonic antigen (CEA) monoclonal antibody MN-14 and chemotherapy in nude mice bearing human MTC xenografts. A preliminary study evaluated doxorubicin, dacarbazine (DTIC),(More)
A conceptual means of obtaining improved bonding between filler particles and the polymeric binders of composites is presented. It involves preparing glass particles that separate into two interconnected vitreous phases when heated to an appropriate temperature, and then etching these to produce a porous surface layer. Candidate glass compositions were(More)
Ronald W. Newsom, Major Professor Gwenn Pasco, Minor Professor Jay H. Shores, Committee Member Kathleen Whitson, Program Coordinator Jan Holden, Interim Chair of the Department of Counseling, Development, and Higher Education M. Jean Keller, Dean of the College of Education Sandra L. Terrell, Dean of the Robert B. Toulouse School of Graduate Studies(More)
Research leading to the application of computer software techniques for handling humanfactors task data generated in support of aerospace system development programs is discussed. It is recognized that data handling techniques must be developed in context with their total operative environment. A concept of an operational data managementsystem for storing,(More)