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BACKGROUND The purpose of this study was to examine if Type 2 diabetes mellitus is a risk factor for dementia in very old age, specifically for Alzheimer's disease (AD) and vascular dementia (VaD). METHODS We evaluated the risk of dementia in relation to Type 2 diabetes using a population-based sample of 702 individuals aged 80 years and older (mean age(More)
We examined change in neuropsychological test performance related to type 2 diabetes mellitus across a 6-year interval. A population-based sample of 274 elderly participants (36 with diabetes and 238 without diabetes) was examined at four occasions at a 2-year interval. The participants were 80-93 years of age (M = 82.8 years) and without dementia at(More)
BACKGROUND diabetes and hypertension are two highly prevalent diseases in the old population. They are highly related such that comorbidity is common. OBJECTIVES to examine (i) the independent impact of the respective diseases on cognitive decline in very old age and (ii) the interactive impact of the two diseases on cognitive decline. SUBJECTS 258(More)
The purpose of this study was to assess the relative importance of age, gender, and education on episodic memory functioning in a population-based sample of healthy individuals, between 90 and 100 years of age. A total of 80 persons completed a face recognition task, immediate and delayed word recall, object recall, and the Mini-Mental State Examination.(More)
The purpose of this study was to examine the cognition-survival relationship among nondemented individuals in late life. The longitudinal design included three examinations at 2-year intervals. At baseline, 466 individuals (age range = 80-98) were examined. During the 6 years of follow-up, 206 individuals died. Four survival groups were defined on the basis(More)
BACKGROUND High midlife body mass index (BMI) has been linked to a greater risk of dementia in late life, but few have studied the effect of BMI across midlife on cognitive abilities and cognitive change in a dementia-free sample. METHODS We investigated the association between BMI, measured twice across midlife (mean age 40 and 61 years, respectively),(More)
Population-based samples of normal old adults and people with major depression (MD), Alzheimer's disease (AD), and coexisting MD and AD (MD + AD) between 90 and 100 years of age were assessed in face recognition, word recall, and object recall. Results indicated a consistent pattern across tasks: no differences between the normal old and the MD participants(More)
Population-based samples of normal old adults, patients with Alzheimer's disease (AD), and patients with vascular dementia (VaD) between 90 and 100 years of age were given a series of episodic memory tasks, assessing face recognition, word recall, and object recall. Results indicated (a) no group differences in those variables reflecting primary memory, and(More)
The importance of preventing and controlling hypertension (HTN) and diabetes mellitus (DM) to mitigate risks to physical health has long been understood by health care professionals. More recently, a growing body of evidence implicates HTN and DM in age-related cognitive decline and risk for dementia, though consensus has yet to be reached on whether older(More)