Lina Sun

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BACKGROUND The development of new therapeutic targets and strategies to control highly pathogenic avian influenza (HPAI) H5N1 virus infection in humans is urgently needed. Broadly cross-neutralizing recombinant human antibodies obtained from the survivors of H5N1 avian influenza provide an important role in immunotherapy for human H5N1 virus infection and(More)
The use of information technology in research and practice leads to increased degree of automation of tasks and makes scientific experiments more efficient in terms of cost, speed, accuracy, and flexibility. Scientific workflows have proven useful for the automation of scientific computations. However, not all tasks of an experiment can be automated. Some(More)
BACKGROUND SFTS virus (SFTSV) is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS) in human. Successful control of SFTSV epidemic requires better understanding of the antigen target in humoral immune responses to the new bunyavirus infection. METHODOLOGY/PRINCIPAL FINDINGS We have generated a combinatorial Fab(More)
In video surveillance system, it is a key factor that extracting moving objects accurately to obtain better monitoring effect. The shadows followed with moving objects may change the object shapes or distort the object. Therefore, it become difficult to extract moving objects accurately. In this paper, According to optical characteristics of shadow, a(More)
This training program is a subsidiary program of Beijing outstanding talents cultivation plan, whose topic is “the study of cultivating model of how to improve young college teachers' teaching practice ability by the application of modern educational technology”. It is mainly designed by the author who took part in it. The detailed processes(More)
Sex differences in song nuclei are evident across songbirds. To explore candidate genes involving in the sexual dimorphism of song nuclei, the present study used suppression subtraction hybridization to identify male-biased genes in the Bengalese finch (Lonchura striata). From 199 clones with an inserted sequence, we obtained a gene (parvalbumin, PV) coding(More)
Understanding the mechanism of protective antibody recognition against highly pathogenic avian influenza A virus H5N1 in humans is critical for the development of effective therapies and vaccines. Here we report the crystal structure of three H5-specific human monoclonal antibodies bound to the globular head of hemagglutinin (HA) with distinct epitope(More)
From the detailed analyses of Web-based Instruction and meaningful discovery learning theory, we can see that under the guidance of meaningful discovery learning theory, Web-based Instruction fully displays the superiority of network. In return, Web-based Instruction also provides the best teaching environment and operation platform, which finally benefits(More)
There are approximately 10(9) proteins in a cell. A hotspot in bioinformatics is how to identify a protein subcellular localization, if its sequence is known. In this paper, a method using fast Fourier transform-based support vector machine is developed to predict the subcellular localization of proteins from their physicochemical properties and structural(More)