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Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining… Expand
Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to determine the… Expand
Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
- S. von Stockenstrom, L. Odevall, +21 authors S. Palmer
- Biology, Medicine
- The Journal of infectious diseases
- 23 February 2015
BACKGROUND The stability of the human immunodeficiency virus type 1 (HIV-1) reservoir and the contribution of cellular proliferation to the maintenance of the reservoir during treatment are… Expand
The Euvichol story – Development and licensure of a safe, effective and affordable oral cholera vaccine through global public private partnerships
Cholera, a diarrheal disease primarily affecting vulnerable populations in developing countries, is estimated to cause disease in more than 2.5 million people and kill almost 100,000 annually. An… Expand
Benchmark Comparison of High and Low Performers to Identify Key Success Factors in the care of Type 2 Diabetes in Sweden
- S. Ekeblad, L. Odevall, T. Holm, Mats Bojestig, Soffia Gudbjörnsdottir, Claes-Göran Östenson
Aims: The Swedish National Diabetes Register (NDR) has shown large geographical differences in treatment outcomes for diabetes patients in primary care, both between and within the 21 county councils… Expand
High levels of genetically-intact HIV in HLA-DR+ memory T-cells indicates their value for reservoir studies.
OBJECTIVE The contribution of HLA-DR+ memory CD4+ T-cells to the HIV reservoir during prolonged antiretroviral therapy is unclear as these cells are commonly excluded when assessing for… Expand
Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites
- E. Lee, S. von Stockenstrom, +19 authors S. Palmer
- Biology, Medicine
- Journal of Virology
- 13 November 2019
HIV-1 persists as an integrated genome in CD4+ memory T cells during effective therapy, and cessation of current treatments results in resumption of viral replication. To date, the impact of… Expand
Oral abstracts of the 21st International AIDS Conference
- J. Symons, A. Chopra, +29 authors S. Palmer
- Journal of the International AIDS Society
- 1 July 2017
MOAA0104–Table 1. Clonal expansion of HIV integration sites CD4 count HIV DNA/10 CD4 cells % Clonal expansion in blood % Clonal expansion in LN % Clonal expansion
Consensus Meeting on International Standards for Oral Whole Cell Killed Cholera Vaccines, 17-18 May 2018, Seoul, Republic of Korea
1International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea 2Department of Bacteriology, National Institute of Biological Standards and Control,… Expand