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Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintainingExpand
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Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to determine theExpand
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Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
BACKGROUND The stability of the human immunodeficiency virus type 1 (HIV-1) reservoir and the contribution of cellular proliferation to the maintenance of the reservoir during treatment areExpand
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The Euvichol story – Development and licensure of a safe, effective and affordable oral cholera vaccine through global public private partnerships
Cholera, a diarrheal disease primarily affecting vulnerable populations in developing countries, is estimated to cause disease in more than 2.5 million people and kill almost 100,000 annually. AnExpand
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Benchmark Comparison of High and Low Performers to Identify Key Success Factors in the care of Type 2 Diabetes in Sweden
Aims: The Swedish National Diabetes Register (NDR) has shown large geographical differences in treatment outcomes for diabetes patients in primary care, both between and within the 21 county councilsExpand
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High levels of genetically-intact HIV in HLA-DR+ memory T-cells indicates their value for reservoir studies.
OBJECTIVE The contribution of HLA-DR+ memory CD4+ T-cells to the HIV reservoir during prolonged antiretroviral therapy is unclear as these cells are commonly excluded when assessing forExpand
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Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites
HIV-1 persists as an integrated genome in CD4+ memory T cells during effective therapy, and cessation of current treatments results in resumption of viral replication. To date, the impact ofExpand
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Oral abstracts of the 21st International AIDS Conference
MOAA0104–Table 1. Clonal expansion of HIV integration sites CD4 count HIV DNA/10 CD4 cells % Clonal expansion in blood % Clonal expansion in LN % Clonal expansion
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Consensus Meeting on International Standards for Oral Whole Cell Killed Cholera Vaccines, 17-18 May 2018, Seoul, Republic of Korea
1International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea 2Department of Bacteriology, National Institute of Biological Standards and Control,Expand