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Asgard archaea illuminate the origin of eukaryotic cellular complexity
The origin and cellular complexity of eukaryotes represent a major enigma in biology. Current data support scenarios in which an archaeal host cell and an alphaproteobacterial (mitochondrial)Expand
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  • Open Access
Exploring microbial dark matter to resolve the deep archaeal ancestry of eukaryotes
The origin of eukaryotes represents an enigmatic puzzle, which is still lacking a number of essential pieces. Whereas it is currently accepted that the process of eukaryogenesis involved an interplayExpand
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  • Open Access
Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis
Significance Aberrant insulin-like growth factor 1 receptor (IGF1R)/insulin receptor signaling in brain has recently been linked to neurodegeneration in diabetes mellitus and in Alzheimer’s disease.Expand
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Confident phylogenetic identification of uncultured prokaryotes through long read amplicon sequencing of the 16S‐ITS‐23S rRNA operon
Summary Amplicon sequencing of the 16S rRNA gene is the predominant method to quantify microbial compositions and to discover novel lineages. However, traditional short amplicons often do not containExpand
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PacBio sequencing of 16S-ITS-23S rRNA operon amplicons
Amplicon sequencing of the 16S rRNA gene is the predominant method to quantify microbial compositions and to discover novel lineages. However, traditional short amplicons often do not contain enoughExpand
P003 IGF1R signalling is essential for neurological symptoms in RA
Introduction In addition to inflammation of the joints, rheumatoid arthritis (RA) has a neurological part consisting of pain, fatigue, depression and cognitive deterioration. These symptoms areExpand
Con fi dent phylogenetic identi fi cation of uncultured prokaryotes through long read amplicon sequencing of the 16 SITS-23 S rRNA operon
Joran Martijn , Anders E. Lind, Max E. Schön, Ian Spiertz, Lina Juzokaite, Ignas Bunikis, Olga V. Pettersson and Thijs J. G. Ettema 1,3* Department of Cell and Molecular Biology, Science for LifeExpand
Amplicon sequencing of the 16S-ITS-23S rRNA operon with long-read technology for improved phylogenetic classification of uncultured prokaryotes
Amplicon sequencing of the 16S rRNA gene is the predominant method to quantify microbial compositions of environmental samples and to discover previously unknown lineages. Its unique structure ofExpand
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