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Bacterial cellulose (BC, also known as microbial cellulose, MC) is a promising natural polymer which is biosynthesized by certain bacteria. This review focused on BC-based materials which can be utilized for skin tissue repair. Firstly, it is illustrated that BC has unique structural and mechanical properties as compared with higher plant cellulose, and is(More)
PTEN is a tumour suppressor frequently mutated in many types of cancers. Here we show that targeted disruption of PTEN leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal stem cells. PTEN-deficient NSCs display neoplasm-associated metabolic and gene expression profiles and generate intracranial tumours in(More)
BACKGROUND AND OBJECTIVE Betatrophin, a novel hormone, is correlated with insulin resistance and promotes pancreatic β-cell growth in mice. The aim of this study was to determine circulating betatrophin levels in overweight or obese children and adolescents. METHODS The following pairs of subjects were included: (i) normal-weight healthy (n = 27) and(More)
Boron efficiency of scion ‘Fengjie-72' is related to its less reduced boron concentration and distribution in leaves, achieved by decreasing the ratio of available boron in roots under boron-deficient conditions. Boron (B) deficiency is widespread in citrus orchards. Previous studies have demonstrated that the B-efficient navel orange scion ‘Fengjie-72'(More)
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated with familial ALS. Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts of familial ALS patients bearing SOD1(More)
Bacterial nanocellulose (BNC) was biosynthesized by Gluconacetobacter xylinus. The surface area, physicochemical structure and morphology of the materials were characterized. Here provides a method for an efficient production of uniform BNC, which is beneficial for the fast characterization and evaluation of BNC. In vitro cytotoxicity of the materials was(More)
A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative(More)
Xeroderma pigmentosum (XP) is a group of genetic disorders caused by mutations of XP-associated genes, resulting in impairment of DNA repair. XP patients frequently exhibit neurological degeneration, but the underlying mechanism is unknown, in part due to lack of proper disease models. Here, we generated patient-specific induced pluripotent stem cells(More)
Plasmids and antibodies Episomal plasmids including pCXLE-hOCT3/4-shp53-F (27077), pCXLE-hUL (27080) and pCXLE-hSK (27078) were all purchased from Addgene (Okita et al., 2011). Antibodies used were purchased from different companies indicated as below: anti-OCT-3/4 (sc-5279) and antiSOX2 (sc-17320) were from Santa Cruz Biotechnology; antiNANOG (ab21624) and(More)
The present paper describes nine new Otacilia species from Southwest China: O. mira sp. nov. (♀, ♂) and O. pyriformis sp. nov. (♀, ♂) from Chongqing, O. papilion sp. nov. (♀, ♂) from Guizhou, O. aurita sp. nov. (♀, ♂), O. digitata sp. nov. (♂), O. leibo sp. nov. (♀, ♂) and O. ovata sp. nov. (♀, ♂) from Sichuan, O. acuta sp. nov. (♀, ♂) and O. flexa sp. nov.(More)