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A part of the tRNA(Leu)(UAA) gene containing a 240-nucleotide group I intron was amplified by PCR from cyanobacterium Synechococcus PCC 6301 genomic DNA. The pre-tRNA synthesized from the cloned PCR product was efficiently self-spliced in vitro under physiological conditions. The gene encoding the tRNA(Leu)(UAA), trnL-UAA, was isolated from a Synechococcus(More)
n Abstract Aflatoxin H, has been suggested as a causative agent for a G to T mutation at codon 249 in the p53 gene in human hepatocellular carcino mas from southern Africa and Qidong in China. To test this hypothesis, nine tumors induced by aflatoxin H, in nonhuman primates were analyzed for mutations in the p53 gene. These included four hepatocellular(More)
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