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Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in lymphoid tissues and is capable of signal transduction. The full-length receptor was expressed in BaF3 cells, which created a functional assay for(More)
Five cases of stress fracture were studied with high-field-strength magnetic resonance (MR) imaging. In all cases, MR images showed bandlike areas of very low signal intensity in the intramedullary space, which were continuous with the cortex. These findings corresponded in location to the sites of fracture or new bone formation noted on radiographs.(More)
  • Y Xu, Y Sun, +11 authors Y Xie
  • 2008
BACKGROUND Human cytochrome P450 2D6 (CYP2D6) genotype may affect the efficacy of tamoxifen treatment in Caucasian women with breast cancer. The most common polymorphism of CYP2D6 in Chinese women is variant 10 (188 C to T). PATIENTS AND METHODS Tamoxifen and 4-hydroxytamoxifen (4OHtam) were measured in the serum of 37 women with breast cancer who were(More)
AIMS We determined the role of the Rho kinase (ROCK) isoforms in diabetes-induced vascular endothelial dysfunction and enhancement of arginase activity and expression. METHODS AND RESULTS Studies were performed in aortic tissues from haplo-insufficient (H-I) ROCK1 and ROCK2 mice and wild-type (WT) mice rendered diabetic with streptozotocin and in bovine(More)
Forebrain γ-aminobutyric acid (GABA) interneurons have crucial roles in high-order brain function via modulating network activities and plasticity, and they are implicated in many psychiatric disorders. Availability of enriched functional human forebrain GABA interneurons, especially those from people affected by GABA interneuron deficit disease, will be(More)
We investigated the role of Bruton's tyrosine kinase (Btk) in FcepsilonRI-dependent activation of mouse mast cells, using xid and btk null mutant mice. Unlike B cell development, mast cell development is apparently normal in these btk mutant mice. However, mast cells derived from these mice exhibited significant abnormalities in FcepsilonRI-dependent(More)
The proliferation of wireless localization technologies provides a promising future for serving human beings in indoor scenarios. Their applications include real-time tracking, activity recognition, health care, navigation, emergence detection, and target-of-interest monitoring, among others. Additionally, indoor localization technologies address the(More)
PURPOSE To analyze the effectiveness of core-needle biopsy for evaluation of possible primary musculoskeletal neoplasms, which often are evaluated with open biopsy. MATERIALS AND METHODS Core-needle biopsy was performed at a tertiary care institution in 141 patients suspected of having a mesenchymal neoplasm. In 85 patients, the lesion was in soft tissue;(More)
MR imaging was performed in eight patients with osteochondromas, and the results were compared with the histologic findings in six of these cases. MR imaging effectively showed the essential anatomic features of lesions and was particularly useful in assessing the presence and thickness of the cartilage cap. The cartilage cap was clearly seen as a region of(More)