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Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice
Results reveal that NIK regulates the transcriptional activity of NF-κB in a receptor-restricted manner and selectively required for gene transcription induced through ligation of LTβ receptor but not TNF receptors.
Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase
Observations show that Nim1 promotes the onset of mitosis by inhibiting Wee1, and Wee1 is hyperphosphorylated in cells that overproduce Nim1.
Differential Regulation of the p 21 / WAF-1 and mdm 2 Genes after High-Dose UV Irradiation : p 53-Dependent and p 53-Independent Regulation of the mdm 2 Gene
Background: DNA damage in mammalian cells stabilizes the p53 protein which then functions as a cell cycle checkpoint by leading to growth arrest or apoptosis. p53 is a transcription factor and
Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis
The reversal effects of Ethaselen on cisplatin resistance in K562/cisplatin (CDDP) cells that were established by pulse-inducing human erythrocyte leukemic cell line K562, which are fivefold more resistant to cisPlatin compared to K562 cells were investigated.
The S. pombe mitochondrial transcriptome.
This work uncovers the complexity of a fungal mitochondrial transcriptome and provides a framework for future studies of mitochondrial gene expression using S. pombe as a model system.
Nif 1 , a novel mitotic inhibitor in Schizosaccharomyces pombe ent of the Wee 1 – Mik 1 pair , as shown by the observation
ent of the Wee1–Mik1 pair, as shown by the observation Lin Wu and Paul Russell1 that wee1– mutants have a wee phenotype (Nurse, 1975), Departments of Molecular Biology and Cell Biology, The Scripps
dnm1 deletion blocks mitochondrial fragmentation in Δfzo1 cells
This study represents the first report of Fzo1 mediator of mitochondrial fusion in S. pombe, and finds that dnm1 mutations could both block mitochondrial fragmentation and rescue respiration growth defect in Δfzo1 single mutant cells.
Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.
The results suggest that trz2 overexpression may cause mitochondrial dysfunction, which is likely to lead to perturbation of iron homeostasis, ROS accumulation and induction of apoptotic cell death in S. pombe.
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53
IKKα functions as a coactivator for CHK1- and p300/CBP-dependent p53 acetylation, which leads to autophagy induction and feedback degradation of IKKα during the arsenite cytotoxic response.