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Consistent deficits in the cholinergic system are evident in the brains of Alzheimer's Disease (AD) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (AChE), and choline acetyltransferase (ChAT), increased butyrylcholinesterase (BChE) activity, and a selective loss of nicotinic acetylcholine receptors (nAChRs).(More)
Toxoplasma gondii is an obligate intracellular parasite that can pose a serious threat to human health by causing toxoplasmosis. There are no drugs that target the chronic cyst stage of this infection; therefore, development of an effective vaccine would be an important advance. Aspartic proteases play essential roles in the T. gondii lifecycle. The(More)
—This paper presents a longitudinal tracking control law for Cooperative Adaptive Cruise Control (CACC) systems in a platoon that can comprehensively enable tracking capability of various spacing policies, designed expected velocity, and designed expected acceleration. Taking into account heterogeneous traffic, i.e., a platoon of vehicles with possibly(More)
An experiment investigating the photoelectron instability has been performed in BEPC at IHEP, China. The betatron oscillation of each bunch was observed and recorded by a single pass beam position monitor system which has a capability to measure the transverse position of every bunch over 16000 turns. The effect of an octupole magnet on the instability was(More)
BACKGROUND Toxoplasma gondii is a widespread intracellular parasite, which infects most vertebrate animal hosts and causes zoonotic infection in humans. Vaccine strategy remains a promising method for the prevention and control of toxoplasmosis. T. gondii GRA4 protein has been identified as a potential candidate for vaccine development. In our study, we(More)
Initial investigation for new active herbal extract with inhibiting activity on JAK/STAT signaling pathway revealed that the extract of Caulis Trachelospermi, which was separated by 80% alcohol extraction and subsequent HP-20 macroporous resin column chromatography, was founded to strongly inhibit IFN-γ-induced STAT1-responsive luciferase activity(More)
Because lubricants may decrease trauma during coitus, it is hypothesized that they could aid in the prevention of HIV acquisition. Therefore, safety and anti-HIV-1 activity of over-the-counter (OTC) aqueous- (n = 10), lipid- (n = 2), and silicone-based (n = 2) products were tested. The rheological properties of the lipid-based lubricants precluded testing(More)
This paper presents a novel technique—Floating Centroids Method (FCM) designed to improve the performance of a conventional neural network classifier. Partition space is a space that is used to categorize data sample after sample is mapped by neural network. In the partition space, the centroid is a point, which denotes the center of a class. In a(More)
Breast cancer is one of the most common tumors related to death in women in many countries. In this paper, a novel neural network classification model is developed. The proposed model uses floating centroids method and particle swarm optimization algorithm with inertia weight as optimizer to improve the performance of neural network classifier. Wisconsin(More)
MicroRNAs (miRNAs) are involved in the epithelial-mesenchymal transition (EMT) process and are associated with metastasis in gastric cancer (GC). MiR-338-3p has been reported to be aberrantly expressed in GC. In the present study, we show that miR-338-3p inhibited the migration and invasion of GC cells in vitro. Knocking down miR-338-3p in GC cells led to(More)