Lin-Lin Guo

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Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease of transformed hematopoietic progenitor cells. The expressions of JunB and CDH13 (cadherin-13) gene as tumor suppressor gene were inactivated by promoter methylation in CML patients. This study was purposed to investigate the methylation difference of JunB and CDH13 gene promoter and(More)
Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human cancer cell lines with IC(50) <30 μM. Structure-activity relationship analysis showed that the introduction of dithiocarbamate side(More)
The first genetic linkage map of Salvia miltiorrhiza was constructed in 94 F1 individuals from an intraspecific cross by using simple sequence repeat (SSR), sequence-related amplified polymorphism (SRAP) and inter-simple sequence repeat (ISSR) markers. A total of 93 marker loci in the linkage map, consisting of 53 SSR, 38 SRAP and 2 ISSR locus were made up(More)
OBJECTIVE To establish the chromatographic fingerprint for Herba Lysimachiae by RP-HPLC. METHODS The sample solutions were prepared by extracting material with boiling water,followed by extracting with BuOH from the aqueous extract and analyzed by RP-HPLC with a Phenomenex C18 column (4.6 mm x 150 mm, 5 microm), gradiently eluted with A (acetonitrile(More)
OBJECTIVE To analyze the floral volatiles of Polyonum cuspidatum flower. METHODS The floral volatiles of P. cuspidaturn flower were investigated by Headspace Sampler GC/MS. RESULTS 21 compounds were separated and determined from P. cuspidatumrn, which amounted to 99.29% of the total volatiles. 5 compounds including (E)-2-hyexenoic acid methyl ester,(More)
Antifreeze protein (AFP) can help organisms survive from freezing condition by thermal hysteresis activity to control ice growth and by recrystallization inhibition activity to inhibit recrystallization of ice granules, respectively. By bioinformatics methods especially protein docking, the newly developed models of surface complementarity were used to(More)
Four new phragmalin limonoids (chukfuransins A-D) were isolated from the twigs and leaves of Chukrasia tabularis. Chukfuransins A (1) and B (2) feature a unique C-15/C-20 linkage proposed to be built by a biogenetic pathway involving Michael addition. Chukfuransins C (3) and D (4) feature the C-15/C-21 linkage. Their structures and absolute configurations(More)
Agricultural management plays an important role in the storage of carbon in soils. The behavior of soil CO2 in an Andisol in two different tillage systems (no tillage and tillage) was studied. Soil-column incubation experiments were performed for a period of 150 days to conduct this study. Soil CO2 flux, under no-tillage and tillage treatments, was observed(More)
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