• Publications
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The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells
The transcriptome of human primordial germ cells (PGCs) from the migrating stage to the gonadal stage is analyzed at single-cell and single-base resolutions and paves the way toward deciphering the complex epigenetic reprogramming of the germline with the aim of restoring totipotency in fertilized oocytes. Expand
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential, revealing a previously unrecognized mechanistic link between specific dietary nutrients, gut microbes, platelet function, and thromBosis risk. Expand
Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled*
All the evidence indicates that Dkk-2C2 signals through LRP proteins, which does not require Dvl, while Wnt protein may employ both Dkk, presumably through Fz, and LRP to achieve more efficient signal transduction. Expand
Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming
It is shown that the genomic locations of 5fC can be determined by coupling chemical reduction with biotin tagging, and roles of active 5mC/5hmC oxidation and TDG-mediated demethylation in epigenetic tuning at regulatory elements are revealed. Expand
Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense
  • X. Wang, Yun Li, +16 authors Sudan He
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 14 October 2014
It is discovered that human herpes simplex virus 1 (HSV-1) infection triggers RIP3-dependent necrosis in host cells and is revealed a previously uncharacterized host antipathogen mechanism. Expand
Air quality impacts of power plant emissions in Beijing.
Control measures planned before 2008 will greatly mitigate the SO(2) and PM(10) pollution, especially alleviating the pressure on the urban area to reach the National Ambient Air Quality Standard (NAAQS). Expand
Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor
It is shown that in the pre-activation state, XLG2 directly interacts with FLS2 and BIK1, and it functions together with AGB1 and AGG1/2 to attenuate proteasome-mediated degradation of Bik1, allowing optimum immune activation. Expand
Two N-Terminal Acetyltransferases Antagonistically Regulate the Stability of a Nod-Like Receptor in Arabidopsis
The crucial impact of N-terminal acetylation on the turnover of one plant NLR, Suppressor of NPR1, Constitutive 1 (SNC1), in Arabidopsis thaliana is shown. Expand
Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death
Human and mouse studies indicate that loss of NUP155 function causes AF by altering mRNA and protein transport and link the NPC to cardiovascular disease. Expand
The Decoy Substrate of a Pathogen Effector and a Pseudokinase Specify Pathogen-Induced Modified-Self Recognition and Immunity in Plants.
It is shown that PBL2, a paralog of BIK1, is similarly uridylylated by AvrAC, which acts as a decoy and enables Avrac detection, and illustrates how decoy substrates and pseudokinases can specify and expand the capacity of the plant immune system. Expand