Lin-Hua Fan

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OBJECTIVE To investigate the effects of schisandrin B (Sch-B) on expression of transforming growth factor-beta1 (TGF-beta1) and signal transduction molecule mRNA in rat lungs exposed to SiO2, and explore the intervention mechanism of Sch-B on pulmonary fibrosis induced by SiO2. METHODS Ninety six Wistar rats were randomly divided into control (normal(More)
OBJECTIVE To investigate the effect of Schisandrin B on mitogen-activated protein kinases (MAPKs) and nuclear factor-KB in rat lungs exposed to silica. METHODS 92 Wistar rats were randomly divided into four groups: Control (20), Silica (30), Sch-B treated 1 group (Sch-B 1) (24) and Sch-B treated 2 group (Sch-B 2)(18). Silicotic animal models received an(More)
It is well recognized that the Wnt pathway, in which β-catenin and Lef-1 are important factors, is associated with many physiological processes, including embryogenesis and postnatal development. The Wnt pathway also plays a critical role in the development of skin. It regulates the formation of the dorsal dermis and epidermal appendages in the skin and the(More)
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