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Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for the induction of many forms of synaptic plasticity, including(More)
The Brief Electricity and Magnetism Assessment BEMA , developed by Chabay and Sherwood, was designed to assess student understanding of basic electricity and magnetism concepts covered in college-level calculus-based introductory physics courses. To evaluate the reliability and discriminatory power of this assessment tool, we performed statistical tests(More)
The association of psychosocial stress with weight gain may have important implications for clinical practice and workplace and public health interventions. To determine whether multiple domains of psychosocial stress were associated with weight gain from 1995 to 2004, the authors analyzed a nationally representative longitudinal cohort of 1,355 men and(More)
[1] We document geodetic strain across the Nepal Himalaya using GPS times series from 30 stations in Nepal and southern Tibet, in addition to previously published campaign GPS points and leveling data and determine the pattern of interseismic coupling on the Main Himalayan Thrust fault (MHT). The noise on the daily GPS positions is modeled as a combination(More)
BACKGROUND We evaluated physicians' training, experience, and practice characteristics and examined associations between their attitudes toward human immunodeficiency virus (HIV)-infected persons who are injection drug users (IDUs) and quality of care. METHODS Cross-sectional surveys were conducted among a probability sample of noninstitutionalized(More)
[1] Geologic investigations of how the Tibetan plateau is currently deforming have focused primarily on its boundary faults. Consequently, how the interior of the plateau deforms remains poorly understood. To fill this gap in knowledge, we conducted field mapping, analysis of remote sensing and digital topographic data, and reinterpretation of existing(More)
INTRODUCTION Critically ill patients with chronic obstructive respiratory diseases (CORD) who require intensive care unit (ICU) admission are at particular risk for invasive bronchial-pulmonary aspergillosis (IBPA). The purpose of this study is to investigate clinical features for rapid recognition of IBPA in critically ill patients with CORD. METHODS We(More)
The minichromosome maintenance (MCM) complex, a replicative helicase, is a heterohexamer essential for DNA duplication and genome stability. We identified Schizosaccharomyces pombe mcb1(+) (Mcm-binding protein 1), an apparent orthologue of the human MCM-binding protein that associates with a subset of MCM complex proteins. mcb1(+) is an essential gene.(More)
Using the techniques of high performance liquid chromatography (HPLC), gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), and immunoblotting, we have analyzed the age-related changes in soluble crystallins of the human lens. A 3 mm core along the optical axis of each lens was frozen-sectioned and the sections were biochemically analyzed(More)
Lipoprotein (a) [Lp(a)], an LDL-like particle, has been proposed as a causal risk factor for CVD among general populations. Meanwhile, both serum Lp(a) and diabetes increase the risk of CVD. However, the relationship between serum Lp(a) and T2D is poorly characterized, especially in the Asian population. Therefore, we conducted a cross-sectional study in(More)