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The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family member is NFAT5,… Continue Reading
Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of transcription… Continue Reading
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos–Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A… Continue Reading
Mutations in the X-linked MECP2 cause Rett syndrome, a devastating neurological disorder typified by a period of apparently normal development followed by loss of cognitive and psychomotor skills.… Continue Reading
To address the fundamental question of “what are the primitives of visual perception”, a theory of topological structure and functional hierarchy in visual perception has been proposed. This holds… Continue Reading
The continually renewing epithelium of the intestinal tract arises from the visceral endoderm by a series of complex developmental transitions. The mechanisms that establish and maintain the… Continue Reading
Localization is a fundamental problem in wireless sensor networks and its accuracy impacts the efficiency of location-aware protocols and applications, such as routing and storage. Most previous… Continue Reading
Nature Communications 6: Article number: 6756 (2015); 10.1038/ncomms7756 Published: April092015; Updated: August212015.
The newly identified p53 homolog p73 can mimic the transcriptional activation function of p53. We investigated whether p73, like p53, participates in an autoregulatory feedback loop with MDM2. p73… Continue Reading
BackgroundCD4+CD25+ regulatory T cells (Treg), which constitute about 2–3% of CD4+ human T cells, are the main contributors to the maintenance of immune tolerance. Cancer patients, including… Continue Reading