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Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive(More)
Functional heterogeneity has been investigated for decades in the hippocampal region of the mammalian cerebral cortex, and evidence for vaguely defined "dorsal" and "ventral" regions is emerging. Direct evidence that hippocampal field CA1 displays clear regional, laminar, and pyramidal neuron differentiation is presented here, based on a systematic(More)
Program slicing is a technique to extract program parts with respect to some special computation. Since Weiser first proposed the notion of slicing in 1979, hundreds of papers have been presented in this area. Tens of variants of slicing have been studied, as well as algorithms to compute them. Different notions of slicing have different properties and(More)
Localization is a fundamental problem in wireless sensor networks and its accuracy impacts the efficiency of location-aware protocols and applications, such as routing and storage. Most previous localization algorithms assume that sensors are distributed in regular areas without holes or obstacles, which often does not reflect real-world conditions,(More)
Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS. Here we show that mutant mice carrying the activation mutation, Ser252Trp [corrected](More)
Apert syndrome is one of the most severe craniosynostosis that is mainly caused by either a Ser252Trp(S252W) or Pro253Arg(P253R) mutation in fibroblast growth factor receptor 2 (FGFR2). As an autosomal dominant disorder, Apert syndrome is mainly characterized by skull malformation resulting from premature fusion of craniofacial sutures, as well as(More)
Adriamycin and docetaxel are two agents commonly used in treatment of breast cancer, but their efficacy is often limited by the emergence of chemoresistance. Recent studies indicate that exosomes act as vehicles for exchange of genetic cargo between heterogeneous populations of tumor cells, engendering a transmitted drug resistance for cancer development(More)
CD4+CD25+ regulatory T cells (Treg), which constitute about 2–3% of CD4+ human T cells, are the main contributors to the maintenance of immune tolerance. Cancer patients, including glioblastoma patients, bear increased number of circulating and tumor infiltrating Treg that exert functional inhibition on tumor-specific T cells. Temozolomide (TMZ) is one of(More)
The present study investigated whether there is a visual counterpart of the auditory mismatch negativity. Event-related potentials were recorded while subjects performed a spatial frequency discrimination task. "Match" and "nonmatch" stimuli were specifically categorized according to whether the second stimulus had the same orientation as the first stimulus(More)
The effect of storage temperature and time on lipid composition of Scenedesmus sp. was studied. When stored at 4°C or higher, the free fatty acid content in the wet biomass increased from a trace to 62.0% by day 4. Using two-step catalytic conversion, algae oil with a high free fatty acid content was converted to biodiesel by pre-esterification and(More)