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Transcriptional regulation by calcium, calcineurin, and NFAT.
The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family member is NFAT5,Expand
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of transcriptionExpand
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos–Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. AExpand
A homeodomain protein related to caudal regulates intestine-specific gene transcription.
The continually renewing epithelium of the intestinal tract arises from the visceral endoderm by a series of complex developmental transitions. The mechanisms that establish and maintain theExpand
The topological approach to perceptual organization
To address the fundamental question of “what are the primitives of visual perception”, a theory of topological structure and functional hierarchy in visual perception has been proposed. This holdsExpand
MDM2 Suppresses p73 Function without Promoting p73 Degradation
ABSTRACT The newly identified p53 homolog p73 can mimic the transcriptional activation function of p53. We investigated whether p73, like p53, participates in an autoregulatory feedback loop withExpand
A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.
We have generated the first mouse model of fibro-blast growth factor receptor 3 (Fgfr3) with the K644E mutation, which accurately reflects the embryonic onset of a neonatal lethal dwarfism,Expand
Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
Human embryonic stem cells (hES cells) have unlimited self-renewal capacity and can differentiate into most, if not all, possible cell types. This unique property makes them valuable not only forExpand
A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures.
Pfeiffer syndrome is a classic form of craniosynostosis that is caused by a proline-->arginine substitution at amino acid 252 (Pro252Arg) in fibroblast growth factor receptor 1 (FGFR1). Here we showExpand
Contribution of Polycomb Homologues Bmi-1 and Mel-18 to Medulloblastoma Pathogenesis
ABSTRACT Bmi-1 and Mel-18 are structural homologues that belong to the Polycomb group of transcriptional regulators and are believed to stably maintain repression of gene expression by altering theExpand