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Bats Are Natural Reservoirs of SARS-Like Coronaviruses
It is reported that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak, and these viruses display greater genetic variation than SARS-CoV isolated from humans or from civets. Expand
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
These results provide the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-CoV, and that intermediate hosts may not be necessary for direct human infection by some bat SL-CoVs, and highlight the importance of pathogen-discovery programs targeting high-risk wildlife groups in emerging disease hotspots. Expand
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.
Among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore, clinical presentation was frequently a mild respiratory tract infection and some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent. Expand
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
Infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein, and SARS-CoV-2-reactive T cells were found in individuals who had recovered from SARS or COVID-19 and in unexposed donors, although with different patterns of immunoreactivity. Expand
Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
It is hypothesized that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs, and highlights the necessity of preparedness for future emergence of Sars-like diseases. Expand
The Exceptionally Large Genome of Hendra Virus: Support for Creation of a New Genus within the FamilyParamyxoviridae
The large genome size (18,234 nucleotides), the unique complementary genome terminal sequences of HeV, and the limited homology with other members of the Paramyxoviridae suggest that HeV should be classified in a new genus in this family. Expand
Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
  • Peng Zhou, Hang Fan, +42 authors Jing-Yun Ma
  • Biology, Medicine
  • Nature
  • 4 April 2018
Analysis of viral samples from deceased piglets shows that a bat coronav virus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease. Expand
Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
An unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families are discovered. Expand
Taxonomy of the order Mononegavirales: update 2016
The updated taxonomy of the order Mononegavirales is presented as now accepted by the International Committee on Taxonomy of Viruses (ICTV). Expand
Hendra and Nipah viruses: different and dangerous
This review describes how studies on the structure and function of henipavirus proteins expressed from cloned genes have provided insights into the unique biological properties of these emerging human pathogens. Expand