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BACKGROUND Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern. OBJECTIVES We investigated the benefits of reducing personal exposure to urban air pollution in patients with coronary heart disease. METHODS In an open randomized crossover trial, 98 patients with coronary heart disease walked(More)
Prion proteins can adopt self-propagating alternative conformations that account for the infectious nature of transmissible spongiform encephalopathies (TSEs) and the epigenetic inheritance of certain traits in yeast. Recent evidence suggests a similar propagation of misfolded proteins in the spreading of pathology of neurodegenerative diseases including(More)
The yeast prion [SWI+], formed of heritable amyloid aggregates of the Swi1 protein, results in a partial loss of function of the SWI/SNF chromatin-remodeling complex, required for the regulation of a diverse set of genes. Our genetic analysis revealed that [SWI+] propagation is highly dependent upon the action of members of the Hsp70 molecular chaperone(More)
INTRODUCTION Blood pressure is a major cause of cardiovascular disease (CVD) and both may increase as outdoor temperatures fall. However, there are still limited data about seasonal variation in blood pressure and CVD mortality among patients with prior-CVD. METHODS We analysed data on 23 000 individuals with prior-CVD who were recruited from 10 diverse(More)
OBJECTIVE To examine the associations between the regular consumption of spicy foods and total and cause specific mortality. DESIGN Population based prospective cohort study. SETTING China Kadoorie Biobank in which participants from 10 geographically diverse areas across China were enrolled between 2004 and 2008. PARTICIPANTS 199,293 men and 288,082(More)
BACKGROUND In many Western populations, blood pressure varies moderately with season and outdoor temperature. Relatively little is known about effects of seasonal changes in blood pressure on the detection and control of hypertension in general populations, especially in low- and middle-income countries. METHODS We analysed cross-sectional data of 57 375(More)
BACKGROUND It remains unclear whether the body mass index (BMI) and blood pressure (BP) profile are clustered within families in Chinese Han population. The aim of this study is to explore familial aggregation and parent-offspring correlations of BMI and blood pressure in Chinese Han population. METHODS 6,369 Han nucleus families, consisting of parents(More)
BACKGROUND In recent years, problems like insufficient coordination, low efficiency, and heavy working load in national communicable disease surveillance systems in China have been pointed out by many researchers. To strengthen the national communicable disease surveillance systems becomes an immediate concern. Since the World Health Organization has(More)