Limei Cheng

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While many physiological control models exist in the literature, none thus far has focused on characterizing the interactions among the respiratory, cardiovascular and sleep-wake regulation systems that occur in sleep-disordered breathing. The model introduced in this study integrates the autonomic control of the cardiovascular system, chemoreflex and(More)
Long-term exposure to intermittent hypoxia and sleep fragmentation introduced by recurring obstructive sleep apnea (OSA) has been linked to subsequent cardiovascular disease and Type 2 diabetes. The underlying mechanisms remain unclear, but impairment of the normal interactions among the systems that regulate autonomic and metabolic function is likely(More)
  • Minnan Xu-Wilson, Eric Carlson, Limei Cheng, Srinivasan Vairavan
  • 2013
Despite advances in adult electrocardiography (ECG) and signal processing techniques, the analysis of fetal ECGs (fECG) is still in its infancy. The clinical potential of abdominal fECG monitoring by placing electrodes over mother's abdomen in antepartum (prior to labor) has been hampered by difficulties in obtaining a reliable fECG. We propose an algorithm(More)
Apnea via breath-holding (BH) in air induces cardiorespiratory adaptation that involves the activation of several reflex mechanisms and their complex interactions. Hence, the effects of BH in air on cardiorespiratory function can become hardly predictable and difficult to be interpreted. Particularly, the effect on heart rate is not yet completely(More)
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