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Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing
Significance C/D box small nucleolar RNAs (SNORDs) are abundant, short, nucleoli-residing, noncoding RNAs that guide the methyltransferase fibrillarin to perform 2′-O-methylation of target RNAs. WeExpand
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Differential DNA methylation of vocal and facial anatomy genes in modern humans
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has provenExpand
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The 5′ untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells
The serotonin receptor 2C (HTR2C) gene encodes a G protein-coupled receptor that is exclusively expressed in neurons. Here, we report that the 5′ untranslated region of the receptor pre-mRNA as wellExpand
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Recent Regulatory Changes Shaped Human Facial and Vocal Anatomy
Identifying changes in gene regulation that shaped human-specific traits is critical to understanding human adaptation. Here, we use dozens of ancient and present-day DNA methylation maps to detectExpand
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Genes Affecting Vocal and Facial Anatomy Went Through Extensive Regulatory Divergence in Modern Humans
Summary Regulatory changes are broadly accepted as key drivers of phenotypic divergence. However, identifying regulatory changes that underlie human-specific traits has proven very challenging. Here,Expand
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Extensive Regulatory Changes in Genes Affecting Vocal and Facial Anatomy Separate Modern Humans from Neanderthals and Denisovans
Changes in gene regulation are broadly accepted as key drivers of phenotypic differences between closely related species. However, identifying regulatory changes that shaped human-specific traits isExpand
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