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We report here the identification of a gene associated with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. A single locus associated with HPT-JT (HRPT2) was previously mapped to chromosomal region 1q25-q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified(More)
STUDY DESIGN A cross-sectional registry and imaging cohort study. OBJECTIVES To study the association between typical symptoms and signs of central spinal stenosis and the minimum cross-sectional area (mCSA) of the cauda equina in patients subsequently undergoing surgery. SUMMARY OF BACKGROUND DATA Relations between mCSA and the symptoms of spinal(More)
Changes in the liver arteries ranging from minimal irregularities in occlusions and development of aneurysms were investigated in 27 patients who received intra-arterial infusion of 5-FU in the hepatic artery. Variations in the arterial caliber peripheral to the hilum of the liver were noted in 13 of the patients. Further investigation of such arterial(More)
F amilial forms of primary hyperparathyroidism (PHPT) constitute a broad group of disorders in which PHPT is either a main or an associated feature. With the advances in disease gene identification, some of the genetic abnormalities underlying familial PHPT have been clarified. 1 2 In hyperparathyroidism2jaw tumour syndrome (HPT-JT; OMIM #145001) the(More)
STUDY PURPOSE To determine the incidence of urinary tract infections, hypertension, back pain, and renal calculi in adult patients with vesicoureteral reflux and reflux nephropathy. METHODS A group of 115 patients (16-60 years of age, median 28 years) with vesicoureteral reflux, combined with reflux nephropathy in 101 patients, first detected between 1967(More)
Parafibromin is a protein product derived from the hyperparathyroidism 2(HRPT2) tumor suppressor geneand its inactivation has been coupled to familial and sporadic forms of parathyroid malignancy. In this study, we have conducted immunohistochemistry on 33 parathyroid carcinomas (22 unequivocal and 11 equivocal) using four parafibromin antibodies directed(More)
For preoperative localization of enlarged parathyroid glands, several imaging techniques have been used. In this study we demonstrate the feasibility of using ultrasonography with fine needle aspiration for parathyroid hormone assay as a preoperative localization procedure in 21 patients with primary hyperparathyroidism. A single adenoma was found in 18(More)
Ultrasound examination was performed on 51 patients with clinically pathological scrotum who all underwent surgery. Twenty patients had extratesticular disease and 31 patients had intratesticular disease. The disease was located correctly by ultrasound in all cases. It was, however, not possible to tell a malignant from a benign lesion, or a teratoma from a(More)
A case history is presented regarding a prostatic utricle cyst associated with unilateral renal agenesis in a young man. The cause of this developmental defect is elucidated. The diagnostic findings using computed tomography and ultrasound examination in addition to intravenous pyelography are reported and the value of these new examinations is emphasized.
Twenty-one children with transient synovitis of the hip were treated in two consecutive groups. In 12 patients aspiration of the synovial effusion was performed within 24 h of admission. In a second group of nine patients no aspiration was performed. There was no other difference in treatment. Joint effusion was studied sonographically in comparison with(More)