Liliana I Viera

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In order to evaluate liposomes as vehicle for oral vaccines the characterization and stability of polymerized and non-polymerized liposomes were examined. Mixtures of 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3 phosphocholine) (DC8,9PC) with saturated 1,2-dimiristoyl-sn-glycero-3-phosphocholine in molar ratio 1:1 were used. Saturated and non-saturated lipids(More)
The changes in absorbance produced when liposomes are subject to increasing osmotic pressures were correlated with the distance at which the undulation, hydration and steric repulsions dominate. It is found that at low pressures, when the bilayers are apart by more than 1 nm, the absorbance decreases with the decrease in the bilayer distance. However, at(More)
When dipalmitoylphosphatidylcholine bilayers dried under vacuum in different concentrations of trehalose are rehydrated in buffer without the sugar they show different physicochemical properties in the gel state in comparison to the normal gel state. Dry DPPC/trehalose mixtures are readily dispersed in buffer below the phase transition showing by electron(More)
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