Lilia M Babé

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in the design of antiviral agents. This focus has resulted in a wealth of new information on the structure and function of these enzymes. Several viral proteases will be described here that exemplify the diversity of structures and biological func-Molecular and Cellular Pharmacology, and tions displayed by these enzymes (Table 1). Viral and Biochemistry and(More)
The dimeric nature of the HIV protease has been exploited to devise a novel mode of inhibiting the enzyme. The use of defective monomers or nonidentical subunits to exchange with wild-type homodimers produces catalytically defective heterodimers. Incubation of the HIV1 or HIV2 protease with a 4-fold molar excess of an inactive mutant of HIV1 leads to 80 and(More)
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