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Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration…
BACKGROUND Asymmetric dimethylarginine (ADMA) plasma levels have been shown to be elevated in diseases related to endothelial dysfunction such as hypertension, hyperlipidemia, diabetes mellitus, and… Expand
Generation of HLA-deficient platelets from hematopoietic progenitor cells.
- C. Figueiredo, L. Goudeva, P. Horn, B. Eiz-Vesper, R. Blasczyk, A. Seltsam
- Biology, Medicine
- 1 August 2010
BACKGROUND Exposure to allogeneic blood products often leads to the development of human leukocyte antigen (HLA) antibodies. Refractoriness to platelet (PLT) transfusion caused by alloimmunization… Expand
G-CSF mobilised granulocyte transfusions in 32 paediatric patients with neutropenic sepsis
IntroductionIn this retrospective, uncontrolled, observational study, the effect of granulocyte colony-stimulating factor (G-CSF)-stimulated granulocyte transfusions (GTX) in neutropenic paediatric… Expand
Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions.
- Christiane D. Wrann, Tobias Laue, +4 authors H. Nave
- Biology, Medicine
- American journal of physiology. Endocrinology and…
Epidemiological studies have indicated that obesity is associated with a higher risk for certain cancers caused by elevated levels of adipocyte-derived hormones. Leptin, one such hormone produced by… Expand
Obesity and the risk of papillary thyroid cancer: a pooled analysis of three case-control studies.
- L. Xu, M. Port, +12 authors E. Sturgis
- Thyroid : official journal of the American…
- 5 June 2014
BACKGROUND There is a correlation between temporal trends of obesity prevalence and papillary thyroid cancer (PTC) incidence in the United States. Obesity is a well-recognized risk factor for many… Expand
CMV-, EBV- and ADV-specific T cell immunity: screening and monitoring of potential third-party donors to improve post-transplantation outcome.
- Cinja Sukdolak, S. Tischer, +11 authors B. Eiz-Vesper
- Biology of blood and marrow transplantation…
- 1 October 2013
Adoptive immunotherapy with virus-specific T lymphocytes can efficiently reconstitute antiviral immunity against cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus (ADV) without causing… Expand
Secondary prophylaxis of invasive fungal infections with combination antifungal therapy and G-CSF-mobilized granulocyte transfusions in three children with hematological malignancies
Fungal infections represent a life-threatening complication for patients receiving chemotherapy or undergoing hematopoietic stem cell transplantation. Historically, antifungal monotherapy is… Expand
Equivalent mobilization and collection of granulocytes for transfusion after administration of glycosylated G-CSF (3 microg/kg) plus dexamethasone versus glycosylated G-CSF (12 microg/kg) alone.
BACKGROUND The aim of this study was to find a regimen for mobilization and collection of granulocytes that combines low-dose G-CSF administration with satisfactory PMN mobilization and apheresis at… Expand
Human Regulatory T Cells of G-CSF Mobilized Allogeneic Stem Cell Donors Qualify for Clinical Application
Recent clinical studies demonstrate the high potency of regulatory T cells (Tregs) to control graft-versus-host disease in hematopoietic stem cell transplantation (SCT). However, the adoptive… Expand
Automated Enrichment, Transduction, and Expansion of Clinical-Scale CD62L+ T Cells for Manufacturing of Gene Therapy Medicinal Products
Multiple clinical studies have demonstrated that adaptive immunotherapy using redirected T cells against advanced cancer has led to promising results with improved patient survival. The continuously… Expand