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Ghrelin, a novel gastric hormone, regulates food intake and energy metabolism via central mechanisms. The peripheral effect of ghrelin on adiposity is poorly understood. We established a stable 3T3-L1 cell line expressing ghrelin to study the direct effect of ghrelin on adipogenesis. Cells overexpressing ghrelin demonstrate significantly attenuated(More)
Recommender systems, especially the newly launched ones, have to deal with the data-sparsity issue, where little existing rating information is available. Recently, transfer learning has been proposed to address this problem by leveraging the knowledge from related recom-mender systems where rich collaborative data are available. However, most previous(More)
Collaborative filtering (CF) aims to predict users' ratings on items according to historical user-item preference data. In many real-world applications, preference data are usually sparse, which would make models overfit and fail to give accurate predictions. Recently, several research works show that by transferring knowledge from some manually selected(More)
Splenic marginal zone lymphoma (SMZL), the most common primary lymphoma of spleen, is poorly understood at the genetic level. In this study, using whole-genome DNA sequencing (WGS) and confirmation by Sanger sequencing, we observed mutations identified in several genes not previously known to be recurrently altered in SMZL. In particular, we identified(More)
Calcium-dependent calpains are a family of cysteine proteases that have been demonstrated to play key roles in both platelet glycoprotein Ibα shedding and platelet activation and altered calpain activity is associated with thrombotic thrombocytopenic purpura. Calpain activators induce apoptosis in several types of nucleated cells. However, it is not clear(More)
Mature adipocytes can revert to a more primitive phenotype and gain cell proliferative ability under the condition of ceiling method, named dedifferentiated fat cells (DFAT cells). These cells exhibit multilineage potential as adipose tissue-derived stromal cells (ADSCs). However, the stem molecular signature of DFAT cells and the difference distinct from(More)