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Manganese superoxide dismutase (MnSOD) is a latent tumor suppressor gene. To investigate the therapeutic effect of MnSOD and its mechanisms, a replication-competent recombinant adenovirus with E1B 55-kDa gene deletion (ZD55) was constructed, and human MnSOD and tumor necrosis factor– related apoptosis-inducing ligand (TRAIL) genes were inserted to form(More)
Recommender systems, especially the newly launched ones, have to deal with the data-sparsity issue, where little existing rating information is available. Recently, transfer learning has been proposed to address this problem by leveraging the knowledge from related recom-mender systems where rich collaborative data are available. However, most previous(More)
Collaborative filtering (CF) aims to predict users' ratings on items according to historical user-item preference data. In many real-world applications, preference data are usually sparse, which would make models overfit and fail to give accurate predictions. Recently, several research works show that by transferring knowledge from some manually selected(More)
On time scales, by using the continuation theorem of coincidence degree theory and constructing some suitable Lyapunov functions, the periodicity and the exponential stability are investigated for a class of delayed high-order Hopfield neural networks HHNNs, which are new and complement of previously known results. Finally, an example is given to show the(More)
In this paper, we study the global stability and the existence of almost periodic solution of high-order Hopfield neural networks with distributed delays of neutral type. Some sufficient conditions are obtained for the existence, uniqueness and global exponential stability of almost periodic solution by employing fixed point theorem and differential(More)
Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism. However, its role in cancer immunopathology and immunotherapy is poorly understood. Using human ovarian cancers as our model, here we show that enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3) and DNA(More)
One limitation of current biodegradable polymeric nanoparticles is their inability to effectively encapsulate and sustainably release proteins while maintaining protein bioactivity. Here we report the engineering of PLGA-polycation nanoparticles with a core-shell structure that act as a robust vector for the encapsulation and delivery of proteins and(More)