Ghrelin, a novel gastric hormone, regulates food intake and energy metabolism via central mechanisms. The peripheral effect of ghrelin on adiposity is poorly understood. We established a stable 3T3-L1 cell line expressing ghrelin to study the direct effect of ghrelin on adipogenesis. Cells overexpressing ghrelin demonstrate significantly attenuated… (More)
The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publica tion Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.
Recommender systems, especially the newly launched ones, have to deal with the data-sparsity issue, where little existing rating information is available. Recently, transfer learning has been proposed to address this problem by leveraging the knowledge from related recom-mender systems where rich collaborative data are available. However, most previous… (More)
Collaborative filtering (CF) aims to predict users' ratings on items according to historical user-item preference data. In many real-world applications, preference data are usually sparse, which would make models overfit and fail to give accurate predictions. Recently, several research works show that by transferring knowledge from some manually selected… (More)
Splenic marginal zone lymphoma (SMZL), the most common primary lymphoma of spleen, is poorly understood at the genetic level. In this study, using whole-genome DNA sequencing (WGS) and confirmation by Sanger sequencing, we observed mutations identified in several genes not previously known to be recurrently altered in SMZL. In particular, we identified… (More)
Previous report showed that Estrogen related receptor α (ERRα) knockout mice had a significant reduction in adipose tissue deposition. Although it was reported that ERRα could promote adipogenesis in several immortalized preadipocytes cell lines, the mechanism behind which is still unclear to date. Besides, the expression pattern of ERRα in white adipose… (More)
Traumatic brain injury (TBI) is a common cause for cognitive and communication problems, but the molecular and cellular mechanisms are not well understood. Epigenetic modifications, such as microRNA (miRNA) dysregulation, may underlie altered gene expression in the brain, especially hippocampus that plays a major role in spatial learning and memory and is… (More)