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Excessive or inappropriate activation of the immune system can be deleterious to the organism, warranting multiple molecular mechanisms to control and properly terminate immune responses. MicroRNAs (miRNAs), ∼22-nt-long noncoding RNAs, have recently emerged as key posttranscriptional regulators, controlling diverse biological processes, including responses(More)
miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). Metastasis suppressor 1 (MTSS1), one target gene of miR-182, plays an important role in the metastasis of cancers. However, it remains unclear what role does function and mechanism of miR-182 and MTSS1play in HCC. miR-182 expression was tested in 86 cases of(More)
BACKGROUND Betatrophin may increase islet β cell proliferation in insulin resistance and irisin may improve glucose tolerance in mice. To examine the relationship between betatrophin and irisin, we investigated it in middle-aged Chinese subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM). METHODS A total of 460 permanent(More)
Purpose: Various information technologies have been designed to assist with the resource management of distribution centres in a typical supply chain. But the humanitarian distribution centre has its own characteristics including hybrid freight types (food, medicine and general living goods, as well as a need to track rescue equipment, vehicles and on-site(More)
— In this paper, we consider the problem of non-parametric estimation of network flow characteristics, namely packet lengths and byte sizes, based on sampled flow data. We propose two different approaches to deal with the problem at hand. The first one is based on single stage Bernoulli sampling of packets and their corresponding byte sizes. Subsequently,(More)
Despite tremendous efforts, development of an effective vaccine against human immunodeficiency virus (HIV) has proved an elusive goal. Recently, however, numerous antibodies have been identified that are capable of neutralizing most circulating HIV strains. These antibodies all exhibit an unusually high level of somatic mutation, presumably owing to(More)
T cell responses in mammals must be tightly regulated to both provide effective immune protection and avoid inflammation-induced pathology. NF-κB activation is a key signaling event induced by T cell receptor (TCR) stimulation. Dysregulation of NF-κB is associated with T cell-mediated inflammatory diseases and malignancies, highlighting the importance of(More)
This paper investigates an approach of integrating software with a minimum risk using Genetic Algorithms (GA). The problem was initially proposed by the need of sharing common software components among various departments within a same organization. Two significant contributions have been made in this study: (1) an assimilation exchange based software(More)