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Excessive or inappropriate activation of the immune system can be deleterious to the organism, warranting multiple molecular mechanisms to control and properly terminate immune responses. MicroRNAs (miRNAs), ∼22-nt-long noncoding RNAs, have recently emerged as key posttranscriptional regulators, controlling diverse biological processes, including responses(More)
miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). Metastasis suppressor 1 (MTSS1), one target gene of miR-182, plays an important role in the metastasis of cancers. However, it remains unclear what role does function and mechanism of miR-182 and MTSS1play in HCC. miR-182 expression was tested in 86 cases of(More)
A population of CD25(+)CD4(+) regulatory T cells (T regs) functions to maintain immunological self tolerance by inhibiting autoreactive T cell responses. CD25(+)CD4(+) T regs are present in low, but steady, numbers in the peripheral lymphoid tissues of healthy mice. Recent studies have shown that IL-2 is an essential growth factor for these cells. How this(More)
Spectrum sensing is a key technology in cognitive radio. Result of cooperative spectrum sensing depends on credibility of local spectrum sensing. But there is a lack of considering it in current schemes. In this paper, we think that different cognitive nodes’ SNRs lead to different reliability of each node’s local sensing results. Firstly,(More)
In currently cooperative spectrum sensing, each secondary user requires some information in order to achieve the vacant spectrum sensing. Energy detection is commonly used in local spectrum sensing. However, performance of cooperative spectrum sensing based on energy detection is damaged due to the noise uncertainty in realistic environment. In this paper,(More)
Gene transfer into B cells by lentivectors can provide an alternative approach to managing B lymphocyte malignancies and autoreactive B cell-mediated autoimmune diseases. These pathogenic B cell populations can be distinguished by their surface expression of monospecific immunoglobulin. Development of a novel vector system to deliver genes to these specific(More)
Purpose: Various information technologies have been designed to assist with the resource management of distribution centres in a typical supply chain. But the humanitarian distribution centre has its own characteristics including hybrid freight types (food, medicine and general living goods, as well as a need to track rescue equipment, vehicles and on-site(More)
Although it has been long recognized that tomato fruit set is linked to the assimilate competition inside plant, quantitative relationship between them have rarely been reported. A reason can be that the dynamic of the internal sink source ratio is hard to measure. In this study, a plant growth model is applied to reveal the ratio between plant assimilate(More)
Despite tremendous efforts, development of an effective vaccine against human immunodeficiency virus (HIV) has proved an elusive goal. Recently, however, numerous antibodies have been identified that are capable of neutralizing most circulating HIV strains. These antibodies all exhibit an unusually high level of somatic mutation, presumably owing to(More)