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miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). Metastasis suppressor 1 (MTSS1), one target gene of miR-182, plays an important role in the metastasis of cancers. However, it remains unclear what role does function and mechanism of miR-182 and MTSS1play in HCC. miR-182 expression was tested in 86 cases of(More)
Purpose: Various information technologies have been designed to assist with the resource management of distribution centres in a typical supply chain. But the humanitarian distribution centre has its own characteristics including hybrid freight types (food, medicine and general living goods, as well as a need to track rescue equipment, vehicles and on-site(More)
— In this paper, we consider the problem of non-parametric estimation of network flow characteristics, namely packet lengths and byte sizes, based on sampled flow data. We propose two different approaches to deal with the problem at hand. The first one is based on single stage Bernoulli sampling of packets and their corresponding byte sizes. Subsequently,(More)
BACKGROUND Tandem mass spectrometry (MS/MS) has been available in China for 8 years. This technique makes it possible to screen for a wide range of previously unscreened inborn errors of metabolism (IEM) using a single test. This 3-year pilot study investigated the screening, diagnosis, treatment and outcomes of IEM in symptomatic infants and children. (More)
PURPOSE To elucidate the phenotypic and biochemical characteristics of a novel mutation associated with autosomal dominant cone-rod dystrophy (adCORD). METHODS Twenty-three family members of a CORD pedigree underwent clinical examinations, including visual acuity tests, standardized full-field ERG, and fundus photography. Genomic DNA was screened for(More)
PURPOSE To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 patients and 421 patients, respectively, with various(More)
Fucoidans, fucose-enriched sulfated polysaccharides isolated from brown algae and marine invertebrates, have been shown to exert anticancer activity in several types of human cancer, including leukemia and breast cancer and in lung adenocarcinoma cells. In the present study, the anticancer activity of the fucoidan extracted from the brown seaweed Undaria(More)
This paper investigates an approach of integrating software with a minimum risk using Genetic Algorithms (GA). The problem was initially proposed by the need of sharing common software components among various departments within a same organization. Two significant contributions have been made in this study: (1) an assimilation exchange based software(More)
The mechanisms by which alcohol causes cell injury are not clear. A major mechanism is the role of lipid peroxidation and oxidative stress in alcohol toxicity. Many pathways have been suggested to play a role in how alcohol induces oxidative stress. Considerable attention has been given to alcohol elevated production of lipopolysaccharide (LPS) and TNFα and(More)