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Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
Tissues from rhesus monkeys were screened by PCR for the presence of sequences homologous to known adeno-associated virus (AAV) serotypes 1–6. DNA spanning entire rep-cap ORFs from two novel AAVs,Expand
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MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2
A major reason for oxaliplatin chemoresistance in colorectal cancer is the acquisition of epithelial–mesenchymal transition (EMT) in cancer cells. The long noncoding RNA (lncRNA), MALAT1, is a highlyExpand
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Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, dose-escalation clinical trial of a recombinant adeno-associated virusExpand
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Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.
A high-throughput screen (HTS) of the MLPCN library using a homogenous fluorescence polarization assay identified a small molecule as a first-in-class direct inhibitor of Keap1-Nrf2 protein-proteinExpand
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Characterization of the size-segregated water-soluble inorganic ions in the Jing-Jin-Ji urban agglomeration: Spatial/temporal variability, size distribution and sources
To investigate the characteristics of aerosols in north China, the samples of water-soluble ions, including anions (F−, Cl−, NO2−, NO3−, SO42−) and cations (NH4+, K+, Na+, Ca2+, Mg2+) in 8Expand
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Deaths among tuberculosis cases in Shanghai, China: who is at risk?
BackgroundInformation about the risk factors associated with death caused by tuberculosis (TB) or death with TB would allow improvements in the clinical care of TB patients and save lives. TheExpand
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Preparation of cationic cotton with two-bath pad-bake process and its application in salt-free dyeing
Cationic cotton was prepared by a designed two-bath pad-bake process with 3-chloro-2-hydroxypropyltrimethylammonium chloride as cationizing reagent to realize recycle utilization of the reagent andExpand
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Effects of reclamation of natural wetlands to a rice paddy on dissolved carbon dynamics in the Sanjiang Plain, Northeastern China
Abstract Natural wetlands play an important role in the global carbon cycle, and loss of dissolved carbon through water has been indicated as one of the most important carbon sources for riverineExpand
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Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root.
Three novel acidic polysaccharides termed PRM1, PRM3 and PRM5 were purified from Rhynchosia minima root using DEAE-52 cellulose and sephadex G-150 column chromatography. Their structures wereExpand
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Simultaneous determination of preservatives in soft drinks, yogurts and sauces by a novel solid-phase extraction element and thermal desorption-gas chromatography.
A novel solid-phase extraction element combined with thermal desorption-gas chromatography (TD-GC) using a pyrolysis-GC system was applied for the determination of the five preservatives - benzoicExpand
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