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Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.
Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.
Structure-based redesign of an edema toxin inhibitor.
Heterodinuclear Pt(iv)-Ru(ii) anticancer prodrugs to combat both drug resistance and tumor metastasis.
- Lili Ma, Rong Ma, Zhigang Wang, S. Yiu, G. Zhu
- Biology, ChemistryChemical communications
- 25 August 2016
These water-soluble bifunctional Pt(iv)-Ru(ii) heterodinuclear complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.
Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action.
Complexation of cisplatin with a p53 activator as a single anticancer agent resulted in synergistically improved cytotoxicity in p53 wild-type but not p53 null human cancer cells, making this compound among the first examples of a Pt(IV) prodrug that directly interacts with the downstream pathway after the formation of Pt-DNA lesions.
A Cancer Cell-Selective and Low-Toxic Bifunctional Heterodinuclear Pt(IV)-Ru(II) Anticancer Prodrug.
An example of heterodinuclear Pt(IV)-Ru(II) complex not only to defeat both drug resistance and cancer metastasis but also having significantly improved cancer cell selectivity and reduced in vivo toxicity than cisplatin is reported.
Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent PtIV Anticancer Prodrug.
A detailed mechanistic study reveals that monochalcoplatin actively enters cells through a transporter-mediated process, and implies a practical strategy for the design of more effective PtIV prodrugs to conquer drug resistance by tuning both cellular uptake pathways and activation processes.
3-Mercaptobutyric Acid as an Effective Capping Agent for Highly Luminescent CdTe Quantum Dots: New Insight into the Selection of Mercapto Acids
CdTe quantum dots (QDs) were synthesized by a modified hydrothermal method with Na2TeO3 as the Te source. Thioglycolic acid (TGA), thiolactic acid (TLA), 3-mercaptopropionic acid (MPA),…
Synthesis and characterization of iron, cobalt and nickel complexes bearing para-phenylene-linked pyridine imine ligand and their catalytic properties for ethylene oligomerization
Abstract The (6 E ,7 E )- N 1 , N 4 -bis((pyridin-2-yl)methylene)benzene-1,4-diamine ligand L-0 was prepared in order to synthesize the corresponding pyridine imine metal (iron, cobalt and nickel)…