The goal of this project is to implement a 10-bit segmented current steering TSMC 0.25µm CMOS digital to analog converter. Binary coded 10-bit data was input to the converter. The converter will convert all combinations of ten bits from digital form into correspondent " staircase " voltage levels. A low pass filter placed after the output terminal of the… (More)
In clinic, many non-small cell lung cancer (NSCLC) patients receive radiation therapy after chemotherapy failure. However, whether the multidrug resistance (MDR) can elevate the radioresistance (RDR) remains unclear. To evaluate the MDR’s effect on the RDR, screen MDR- and RDR-related proteins in human lung adenocarcinoma (HLA) cells and tissues A549, and… (More)
Anti-angiogenesis has been proposed as an effective therapeutic strategy for cancer treatment. Pigment epithelium-derived factor (PEDF) is one of the most powerful endogenous anti-angiogenic reagents discovered to date and PEDF gene therapy has been recognized as a promising treatment option for various tumors. There is an urgent need to develop a safe and… (More)
A phase lock loop is a closed-loop system that causes one system to track with another. More precisely, a PLL can be perceived as a circuit synchronizing an output signal with a reference or input signal in frequency as well as phase. High-performance phase lock loops are widely used within a digital system for clock generation, timing recovery, and to… (More)
This paper presents the design of a first-order continuous-time sigma-delta modulator. It can accept input signal bandwidth of 10 kHz with oversampling ratio of 250. The modulator operates at 1.8 V supply voltage and uses 0.18 um CMOS technology. It achieves a level of 60 dB SNR..
Accumulating evidences have suggested the existence of breast cancer stem cells (BCSCs), which possess the potential of both self-renewal and differentiation. The origin of BCSCs might have relationship to the development of normal mammary stem cells. BCSCs are believed to play a key role in the initiation, recurrence and chemo-/radiotherapy resistances of… (More)
Hypertension has become a significant global public health concern and is also one of the most common risk factors of cardiovascular disease. Recent studies have shown the promising result of peptides inhibiting angiotensin converting enzyme (ACE) in lowering the blood pressure in both animal models and humans. However, the oral bioavailability and… (More)
Cervical cancer presents extremely low PEDF expression which is associated with tumor progression and poor prognosis. In this study, folate receptor α (FRα)-targeted nano-liposomes (FLP) were designed to enhance the anti-tumor effect by targeting delivery of exogenous PEDF gene to cervical cancer cells. The targeting molecule F-PEG-Chol was firstly… (More)