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Postacquisition denoising of magnetic resonance (MR) images is of importance for clinical diagnosis and computerized analysis, such as tissue classification and segmentation. It has been shown that the noise in MR magnitude images follows a Rician distribution, which is signal-dependent when signal-to-noise ratio (SNR) is low. It is particularly difficult(More)
Perfusion imaging is a useful adjunct to anatomic imaging in numerous diagnostic and therapy-monitoring settings. One approach to perfusion imaging is to assume a convolution relationship between a local arterial input function and the tissue enhancement profile of the region of interest via a "residue function" and subsequently solve for this residue(More)
The three-dimension (3D) magnetization-prepared rapid gradient-echo (MP-RAGE) sequence is one of the most popular sequences for structural brain imaging in clinical and research settings. The sequence captures high tissue contrast and provides high spatial resolution with whole brain coverage in a short scan time. In this paper, we first computed the(More)
The objective of this study was to develop a simple and rapid method that could detect and discriminate four specific pesticides (isocarbophos, omethoate, phorate, and profenofos) using a single aptamer-based capture procedure followed by Surface Enhanced Raman Spectroscopy (SERS). The aptamer is a single stranded DNA sequence that is specific to capture(More)
The objective of this study was to establish a loop-mediated isothermal amplification (LAMP) method for the detection of F5 fimbriae gene in Enterotoxigenic Escherichia coli. A set of four primers were designed based on the conservative sequence of coding F5 fimbriae. Temperature and time condition, specificity test, and sensitivity test were performed with(More)
The feasibility of utilizing a handheld Raman spectrometer for surface-enhanced Raman scattering detection was evaluated on the pesticide ferbam. A layman's "answer box" was established for semi-quantifying the risk level of ferbam. This study advanced the application of a handheld Raman spectrometer to on-site evaluation of trace amounts of analytes.
State of art phase locked loop (PLL) design methodologies and techniques are always of many mixed-signal circuit designers' interests. In this paper, a fully differential PLL having good common-mode noise rejection (low phase noise) has been designed and demonstrated using TSMC 0.25µm CMOS technology. The design and demonstration included a dead zone(More)
iv ACKNOWLEDGMENTS I would like to thank my advisor Dr. Lili He for her full support and encouragement throughout my research. The experience I gained and opportunities I had in this lab greatly exceeded my expectations, for which I am grateful. I would also like to thank Dr. Decker and Dr. Zhang for being members on my committee and for their input on my(More)