Learn More
BACKGROUND One facet of the complexity underlying the biology of HIV-1 resides not only in its limited number of viral proteins, but in the extensive repertoire of cellular proteins they interact with and their higher-order assembly. HIV-1 encodes the regulatory protein Tat (86-101aa), which is essential for HIV-1 replication and primarily orchestrates(More)
BACKGROUND The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Signal (NLS) by multiple import factors, which include(More)
Although the functional roles of zinc finger-containing glycine-rich RNA-binding proteins (RZs) have been characterized in several plant species, including Arabidopsis thaliana and rice (Oryza sativa), the physiological functions of RZs in wheat (Triticum aestivum) remain largely unknown. Here, the functional roles of the three wheat RZ family members,(More)
Although recent analysis of proteomes in specific cellular organelles of plants has demonstrated that more than 2,000 nuclear-encoded proteins are targeted to the chloroplast, the physiological functions of a majority of the proteins in chloroplasts are largely unknown. Here, we investigated the functional role of a chloroplast-targeted RNA-binding protein(More)
Tat and Rev are equally critical for HIV-1 replication and work in a sequential manner: first, transactivation of the HIV-1 LTR by Tat, followed by nuclear export of partially spliced and unspliced viral transcripts by Rev. Both functions require Tat and Rev to be imported to the nucleus, a process mediated by molecular recognition of their homologous(More)
  • 1