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To clarify the brain mechanism for multifeature stimulus comparison, subjects matched the features of two serial visual stimuli in pairs. Stimulus pairs were of four categories: C-S-, color same, shape same (match); C-S+, color same, shape different (shape mismatch); C+S-, color different, shape same (color mismatch); C+S+, color different, shape different(More)
Event-related potentials (ERPs) were recorded in subjects while they were performing a matching task. The focus of the present study was on the contributions made by ERP recording to revealing the time-course of multi-conflict information processing in the brain during visual attention. Participants were instructed to discriminate whether the attributes of(More)
BACKGROUND Berberine (BBR) has gained attention for its vast beneficial biological effects through immunomodulation, anti-inflammatory and anti-apoptosis properties. Inflammatory and apoptosis damage play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. The aim of this study was to explore BBR's effect in(More)
BACKGROUND Inflammatory and oxidative damage play a pivotal role in cerebral ischemic pathogenesis and may represent a therapeutic target. Octreotide (OCT) has been proved to elicit a variety of biological effects through its anti-inflammatory and anti-oxidant properties in the treatment of severe acute pancreatitis and ischemia-reperfusion injury in retina(More)
BACKGROUND Oxidative and inflammatory damages have been suggested to play an important role in cerebral ischemic pathogenesis, and provide promising therapeutic strategies for stroke. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a pleiotropic transcription factor, has been shown to play a key role in protecting cells against oxidative injury in(More)
Inflammatory damage plays an important role in cerebral ischemic pathogenesis. HMGB1-induced NF-kappaB activation pathway has been gaining recognition as a key contributor to the proinflammatory response. Tanshinone II A (Tan II A) has been proved to elicit a series of biologic effects through its antiinflammatory property. But the mechanism underlying is(More)
Cell therapies are increasingly recognized as a promising option to augment the limited therapeutic arsenal available to fight ischemic stroke. During the last two decades, cumulating preclinical evidence has indicated a substantial efficacy for most cell treatment paradigms and first clinical trials are currently underway to assess safety and feasibility(More)
Inflammatory processes play a key, mainly detrimental role in the pathophysiology of ischemic stroke. Currently, HMGB1-induced NF-kappaB activation pathway has been recognized as a key contributor to the proinflammatory response. It has been proved that chronic administration and pre-treatment with statins could protect brain tissue against ischemic injury.(More)
T cells are accumulated in the lungs of chronic obstructive pulmonary disease (COPD) patients. Intraepithelial T cells, expressing the integrin αE (CD103) β7, and regulatory T cells have been implicated in pathogenesis of the disease. We asked whether COPD patients and smokers have altered frequencies of these T cells and if their phenotypes differ. A total(More)
It is unclear whether crossmodal information conflict can initiate the conflict processing system indexed by a component of the event-related potential (ERP) called the N270, which previously has been observed only for visual conflict. ERPs were recorded in ten subjects, while they were engaged in a visual-auditory discrimination task. A visual stimulus of(More)