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The production of L-tryptophan was increased by reducing acetate accumulation through a decrease in acetate kinase activity by gene deletion. The effects of disruption of the genes for acetate kinase (ackA) and an enzyme with propionate/acetate kinase activity (tdcD) on L-tryptophan production were investigated. The ackA and/or tdcD deletion mutants(More)
Dissolved oxygen (DO) is a key parameter for the production of L-tryptophan, and maintenance of appropriate DO levels can be used to increase the formation of L-tryptophan and reduce the accumulation of acetate and glutamate. In addition, controlling the level of DO by adjusting the feeding rate of glucose solution affects the concentration of glucose in(More)
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