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Antitumor-promoting constituents from Dioscorea bulbifera L. in JB6 mouse epidermal cells.
An antitumor-promoting effect was found in the extracts/ingredients of a plant used as a traditional medicine in mainland China, using the neoplastic transformation assay of mouse epidermal JB6 cellExpand
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
Two new isomeric alkaloids were isolated from the CHCl3 extract of the leaves of Uncaria rhynchophylla and exhibited inhibitory activity on lipopolysaccharide (LPS)-induced NO release in primary cultured rat cortical microglia. Expand
Three anti-tumor saponins from Albizia julibrissin.
Three new triterpenoid saponins were isolated from the stem bark of Albizia julibrissin Durazz by using chromatographic method and displayed significant anti-tumor activities in vitro against PC-3M-1E8, HeLa, and MDA-MB-435 cancer cell lines at 10microM assayed by SRB and MTT methods. Expand
High-performance liquid chromatography method for determination of carnosic acid in rat plasma and its application to pharmacokinetic study.
A sensitive and reproducible high-performance liquid chromatography method with ultraviolet detection (UV) was developed and successfully used to study the pharmacokinetics and bioavailability of CA in rats. Expand
Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa.
Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.)Expand
Constituents from anti-tumor-promoting active part of Dioscorea bulbifera L. in JB6 mouse epidermal cells
The anti-tumor-promoting effect was found in the 75 % ethanol extracts of the rhizomes of Dioscorea bulbifera L. using the neoplastic transformation assay of mouse epidermal JB6 cell lines. The EtOAcExpand
Preparative isolation and purification of acteoside and 2'-acetyl acteoside from Cistanches salsa (C.A. Mey.) G. Beck by high-speed counter-current chromatography.
High-speed counter-current chromatography was applied to the separation and purification of phenylethanoid glycosides (PhGs) acteoside and 2'-acetylacteosides from Cistanches salsa and revealed that the two main PhGs were over 98% purity. Expand
Antitumor-promoting constituents from Chaenomeles sinensis KOEHNE and their activities in JB6 mouse epidermal cells.
Primary screening of antitumor-promoting activity using soft agar colony assays with JB6 cells was employed to isolate 22 compounds from Chaenomeles sinensis KOEHNE, and betulinic acid showed more potent activity than betulin (5), which has a C-28 hydroxymethyl group. Expand
Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs), which is traditionally used in China to treat cerebrovascular and cardiovascular diseases. Expand
Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development
Deuterium substitution as a viable approach for creating novel therapeutic agents with properties potentially differentiated from existing drugs is validated by synthesizing two novel deuterated ivacaftor analogs, CTP-656 (d9-ivacaftors) and d18-ivACaftor. Expand