Lijuan Zheng

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The genome-wide distribution patterns of the '6th base' 5-hydroxymethylcytosine (5hmC) in many tissues and cells have recently been revealed by hydroxymethylated DNA immunoprecipitation (hMeDIP) followed by high throughput sequencing or tiling arrays. However, it has been challenging to directly compare different data sets and samples using data generated(More)
Pituitary adenylate cyclase activating peptide-38 (PACAP-38), PACAP-27 and vasoactive intestinal polypeptide (VIP) increased intracellular cAMP content in human neuroblastoma NB-OK-1 cells transiently. PACAP and VIP also arrested cell growth and induced morphological differentiation, which lasted for 24 h in spite of removal of PACAP-38 and PACAP-27. The(More)
This work was conducted to determine whether congenital stationary night blindness (CSNB), which is caused by a Cacna1f mutation, could affect development of second-order neurons in the retina, such as horizontal cells (HCs). The CSNB rats and age-matched wild type rats were sacrificed at postnatal days (PND) 15, 30 and 60. Morphometric analyses of HCs,(More)
Collaborative filtering is one of the most frequently used techniques in personalized recommendation systems. But currently used user-based collaborative filtering recommendation algorithm and the collaborative filtering recommendation algorithm based on item rating prediction has disadvantage in similarity computation method. Basing on this disadvantage,(More)
Universal network and pervasive service is one kind of new network architecture. In this architecture, in order to guarantee the security of access network and terminal, terminal access control and access network authentication must both be implemented. Terminal unified access control method based on identifier realizes unified access control of various(More)
In order to avoid slow-convergence and local convergence of simple genetic algorithm (SGA ) for intelligent test paper generation, a kind of improved genetic algorithm (IGA)has been proposed in this paper. This algorithm uses unceasing elimination of similar individual method to quickly enlarge the search space and to stabilize the individual diversity of(More)
Regulation of enhancer activity is important for controlling gene expression programs. Here, we report that a biochemical complex containing a potential chromatin reader, RACK7, and the histone lysine 4 tri-methyl (H3K4me3)-specific demethylase KDM5C occupies many active enhancers, including almost all super-enhancers. Loss of RACK7 or KDM5C results in(More)