Lijuan Xing

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Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS). Although the paralogous phosphorylation site S714 in PER1 is conserved in mice, its specific function in circadian organization remains unknown. Here, we find that the(More)
The circadian clock has a central role in physiological adaption and anticipation of day/night changes. In a genetic screen for novel regulators of circadian rhythms, we found that mice lacking MAGED1 (Melanoma Antigen Family D1) exhibit a shortened period and altered rest-activity bouts. These circadian phenotypes are proposed to be caused by a direct(More)
Circadian clocks allow organisms to orchestrate the daily rhythms in physiology and behaviors, and disruption of circadian rhythmicity can profoundly affect fitness. The mammalian circadian oscillator consists of a negative primary feedback loop and is associated with some 'auxiliary' loops. This raises the questions of how these interlocking loops(More)
BACKGROUND Sudden death syndrome (SDS) of soybean caused by Fusarium virguliforme spreads and reduces soybean yields through the North Central region of the U.S. The fungal pathogen and Heterodera glycines are difficult to manage. METHODOLOGY/PRINCIPAL FINDINGS The objective was to determine the contributions of H. glycines and F. virguliforme to SDS(More)
Understanding the mechanism underlying the physiological divergence of species is a long-standing issue in evolutionary biology. The circadian clock is a highly conserved system existing in almost all organisms that regulates a wide range of physiological and behavioral events to adapt to the day-night cycle. Here, the interactions between hCK1ϵ/δ/DBT(More)
In the core mammalian circadian negative feedback loop, the BMAL1-CLOCK complex activates the transcription of the genes Period (Per) and Cryptochrome (Cry). To close the negative feedback loop, the PER-CRY complex interacts with the BMAL1-CLOCK complex to repress its activity. These two processes are separated temporally to ensure clock function. Here, we(More)
Considering the multi-variable, nonlinearity, time lag and time variation characters of air conditioning systems, it is difficult for traditional Proportional Integral Derivative (PID) control to get good control performance.A compound control strategy based on cerebellar model articulation controller (CMAC) and PID controller is used to the system.(More)
A finite element model is constructed to analyze the steady temperature field in a ceramic/metal composite FGM plate under heating boundary. From numerical calculation, when T<sub>0</sub> = T<sub>a</sub> = 300 K and T<sub>b</sub> = 1 800 K, the steady temperature field distributions in the plate were obtained. The numerical results show that the temperature(More)
The convective heat transfer steady heat conduction in a Ti-6Al-4V/ZrO2 composite FGM plate considered temperature dependency was analyzed by nonlinear finite element method. From numerical calculation, when, T0=300K, Ta=500K and Tb=1 650K, the steady heat conduction distributions in the plate were obtained. The numerical results show that the temperature(More)
Considering the multi-variable, nonlinearity, time lag and time variation characters of Variable Air Volume (VAV) air conditioning systems, it is difficult for traditional Fuzzy Logic Controller (FLC) or Proportional Integral Derivative (PID) control to get good control performance. In order to overcome the shortcoming of conventional controller, the fuzzy(More)
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